Thank you to all using their energy and expertise to unravel this. This has been very helpful If you do plan on asking a question at the NIH...
Thanks for highlighting that! ETA - If he is requiring PEM in all patients, he will hopefully update the info in clinicaltrials.gov. On the other...
Bolding added I believe these are two of Dr. Younger's three studies as listed in ClinicalTrials.Gov 1. Assessment of Neuroinflammation in...
So here's where I'm confused... @Ravn above noted: And the point of Workwell's Timeline slide is that pwME can learn early signs of...
Thanks, @Trish. That's surprisingly good.
Thanks for that and good to remember that OI can be playing an overlapping role. I don't know if this person would describe head pressure like...
Another question to clarify - is there a standard definition for exercise intolerance? I ask because it seems that some LC clinical guidance and...
Great discussion in this thread, especially separating out mechanisms from symptoms and change in function Just to clarify - How do you define...
I think this is an important point. Reviewer #4, (appears to be Tony Komaroff, see p 6), questioned how they could have found no cognitive issues...
Not sure if this goes here or in the other thread. The paper noted: But this thread describes the high rate of failure of pwME on the EEfRT...
I believe their point is that the selected participants did not reflect the spectrum of severity of ME. If I remember correctly, the average...
This is just an additional paper from CDC's multi-site "MCAM" study, initiated in 2011. It's typical of CDC to dribble out papers from their...
Of course. I was not saying there weren't. But redefining PEM as "feelings of discomfort" and then virtually ignoring PEM is a pretty big problem...
The question of whether PEM was present or not is a nuanced one. They note the cases were adjudicated by experts and the supplemental data said...
In the Discussion, they say: "Moreover, testing of effort preference and the participants’ own words are consistent with this finding [on central...
Immunoglobulin can be prescribed to people with common variable immune deficiency (CVID), which is diagnosed by specific biomarkers. This can...
This looks very useful. One question - I tried using this to score a severely ill patient I know and wasn't sure how to address the cumulative...
I've been collating a list of ME/CFS provocation studies and there aren't many studies with cognitive challenges. Here's one evaluating autonomic...
In case it's helpful In case it's helpful, here's a transcript of Dr. Griffin's discussion on the Appleman paper Edited to replace the link...
Excellent discussion of the article.
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