Yes, definitely. The ATG13 theory for example predicts that rapamycin will improve the symptoms since it reduces ATG13. They don't know yet if the...
Not sure if I'd agree. Model is valid as long as it can predict. Nobody really knows of how quantum mechanics work, but it's still valid. The...
I seem to remember an effort to put together a minimum set of phenomena that any hypothesis must explain, lead by @rvallee? Maybe this is a good...
The 5 items on DSQ-PEM all concerns fatigue. If fatigue is going to be the measure, then the time spend lying down would be simpler to measure and...
Any idea where I can find (HighY vs LowY) after X? I'm presuming Y is ATG13 and X is Rapamycin.
I went through previous threads on ATG13 to see if I missed something. All I could find was pretty much what's on this thread: high ATG13 in...
I had to think about this for a sec since all population (ME/CFS) in their trial presumably have highY (high ATG13) to start with. But then, it...
Why not just trial properly for the ME/CFS responses if they are trialing for ME/CFS? We don't know if the intermediate markers are actually...
I don't fully understand the reason for not including the control, but it appears they are trialing primarily for the ATG13 response to Rapamycin,...
The software/hardware analogy refers to function/physiology in case of the brain. A computer needs to be programmed to function, and replacing...
I agree: foisting psychology without reliable data can do huge harm. I'm strictly limiting the possibility of "software" problem to well-defined...
Firmware is basically unmodifiable software written in read-only memory. Hardware never becomes software. Memory is a hardware, but it is not...
Because of the possibility that neuronal circuitry/connections can be trained/retrained? Again, there are instances of these. I only can speak...
That's probably true insofar as the brain circuitry is made of neurons.
I wouldn't advise it. 30 sec is plenty of duration to trigger PEM depending on what you do. Squatting down a couple of times used to give me PEM...
I'm referring to so called "software" problem. There are instances of maladaptive automatic motor responses to sensory input. That's not too...
I don't follow FND, so I'll have to take your word if you are saying there hasn't been any RCT. Googling seems to indicate otherwise, however (The...
I asked AI too: "The prognosis for organic vision loss depends entirely on the underlying cause, but generally, if left untreated, most cases of...
You said the eye muscle contraction was a structural change. I said that the muscle action is happening without physical intervention or my...
How would a vision loss improve over time?
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