I did a kind of experiment on myself while I had about 5 weeks of post-COVID symptoms (mostly cognitive issues + light sensitivity + fatigue,...
The problem with consensus is that there will always be subjectivity and bias involved in determining it. Assessments of "relevance" are going to...
In strongly agreeing with this I would also add as a general comment to readers that I think tissue context always needs to be front and centre...
If I am reading this right their ME/CFS data is the RNAseq data from the Wallitt study muscle samples. DNA -> RNA -> protein -> metabolic...
My guess is regulatory disarray. Something in metabolism / signalling going wrong that has wide ranging knock-on effects that include changes to...
ay, there’s the rub edit: Hi Chris, I didn't realise this was you. No wonder you were making so much sense. HAHAHA
Posting a paper here: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6690029/ A good resource for those who want context needed to understand just...
Will discuss with the person we settle on :)
If anybody knows someone very experienced and composed at taking blood in VIC, please send them my way. We need a phlebotomist for the severe pwME...
Thanks Hutan, that confirms my gut suspicions but I wasn’t certain enough to comment. Good to know.
"Using flow cytometry, we compared mitochondrial bioenergetic parameters in CD19 B cells as well as CD4 and CD8 T cell lymphocyte populations....
We have intentionally excluded family in the past so trust me I understand. We will exclude family members with known history of similar or...
Hadn't thought of this, I will look into it, thank you. On another note, if anybody has family or friends who may be interested as healthy...
Making sense of gut data is very difficult due to the number of influencing factors so work like this is extremely important.
I only wish that there was a way to access those too severe to use the internet beyond lucking out with their carers. Thank you everybody else...
I am absolutely shocked by how many clinicians I have met who treat anecdotal information with less skepticism than published studies or trials.
Hi everybody, I finally have the ethics in place to begin recruiting for our recently funded Mason Foundation study. ICC criteria. Healthy...
Such studies would happen more with better funding!!!
Happy to report that upon another look this paper seems to replicate closely with my own work I just checked the unadjusted* mito red...
LDs are important in the innate immune response so differences in their dynamics in a pathogen context make sense. If there are LD dynamics...
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