RCTs are NOT the gold standard. Properly designed double blinded RCTs with objective outcome measures are the "gold standard" (for clinical...
On Sharpe's comments regarding funding David Tuller, a quest editorial -...
I still do not have a twitter account for this reason. However it is very good for sending alerts. Its also very good for live tweeting of...
This achieves the same goal as rolling out national CBT treatments or rounding patients with complex diseases up into quack diagnoses like MUS,...
Yes, diagnostic methods alter analysis outcomes. Its why Oxford is so flawed. Selection bias is one of the huge biases in research. Naturally I...
Yes, those rare days indicate that whatever is going on is some kind of biochemical switch. If we can figure it out we might be able to switch it...
This issue has come up with the biochemistry many times. There seems to be about a one-third/two-third split. This means they are in different...
I have a blog that discusses this in the context of psychogenic diagnoses, on PR -...
We had a brief experiment with trying to create an age of reason. It failed. Right now things appear to be going backwards, though we have...
Can we sign the open letter? If so we should put it to a membership vote. I would vote to do so.
My point is that perceived symptoms and underlying biochemistry are not the same. The type of fatigue I often get that leads to PEM if I push...
The problem is that fatigue is not a simple thing, and its not precise. Its like saying pain, or being sick, or depression. Its a general term. We...
Currently this is done via the two day CPET or metabolic studies. Brain metabolic studies have been done for a very long time in CFS and ME. We...
Any study using only the Chalder Fatigue Scale needs to be looked at very carefully as its not a very good scale and its hard to assess outcomes.
Subjective reports are never great but are OK if proper blinding occurs.
This is my experience. I have also had long periods, lasting months, where this energy deficit still occurred and there was no fatigue. Fatigue is...
Neutraceutical as a term is at least decades old. Its about using nutritional supplements as a drug, not just to restore nutritional balance....
@Lisa108, I am wondering if we should adopt that unfortunate pigeon as our mascot?
I did early morning sunlight for years, it helped in the early days. Light seems to have little effect now.
I don't think we know enough to discuss what is typical. In my case it was about twenty years from severe insomnia to non-24 ... maybe. Or maybe...
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