This is a collaboration between us and neuropsych researchers that work with children. Their expertise put together the decision on scales to use...
Lack of evidence for cortisol is similar to most other findings. We have threads that we have to pull on a little more to get that evidence. Is it...
There appears to be a lot of confusion around the language we used, that sounds like we failed to communicate in a simple way and will do better...
Yes it would be a way to observe some of the exertion that isn't just walking (step count) or being upright (up time). I think at the very least...
We were just listing all the types of information that can be collected to interpret understanding of an individual or a disease. It wasn't...
https://translational-medicine.biomedcentral.com/articles/10.1186/s12967-024-05915-z Machine learning and multi-omics in precision medicine for...
Well there seems to be a expected spread along the x-axis for Cardiac Output, which is what you'd expect as heart just doesn't instantly pump...
AI seems to have acquired the unfortunate human trait of sounding extremely confident even when obviously wrong.
Yes I pushed back about a lack of evidence and they agree there is a lack of evidence but added that the research to produce evidence hadn't been...
Yes agreed. Not stuck to the concept of PEM and energy or capacity. It does seem like the most often discussed connection but best to keep the...
I think the failing in the definitions of ME/CFS is that the clinicians and advocates defined the disease around symptoms in such a way to be...
I've had it explained to me by those that propagate GET and CBT that they think that it's kind of like central sensitisation but with fatigue...
If we were to say PEM is caused by energy being expended beyond a certain level then this would make sense. Patients discuss limiting exertion...
I think syndrome is probably right for the collection of symptoms presented. Postural Orthostatic Tachycardia is present in healthy people, that...
So do you think the nervousness precipitated the PEM or did the nervousness create the insomnia and being awake for so long precipitated the PEM?
Interesting discussion on PEM. What is the range of time before PEM do you recognise its coming?
I have heard from patients that experience immediate PEM such that they describe this red flush that starts in the face and spreads. I am...
The illness process is a broad term to cover many aspects of difference. I believe that part was initially a lot longer and shortened down. It's...
Yes it's well underway, recruitment ends very soon and data analysis will begin. Yes protocol paper took a while to get published but we...
That would be interesting to know. The delay differs between people (see DOMS as an example) but I think the fact that people say the delay in PEM...
Separate names with a comma.
