I'm not sure if many people know this but myself and Rob Phair developed the itaconate trap hypothesis. We were looking for pathways to explain...
HRV is typically shown to be lower during stress, so the idea that people have been using is that low HRV is predictive of feeling worse. We are...
The delay in PEM is very likely related to RNA, there are many processes in the body that take 24-48 hours to alter path. The exacerbation that...
Depends on the study, certainly severity matters if you were to develop an objective marker for clinical trials. It remains an important need for...
Hypertension is in reference to ongoing elevated blood pressure at rest. Orthostatic hypotension is the dramatic drop and sustained drop of blood...
We also managed to get a US Defense grant for this project. We're excited about this project, had to set it up as a clinical trial, so a lot more...
It's possible that people said they were diagnosed but had since improved to a significant degree while still holding the CFS diagnosis. There...
Yeah the supplementary files are loaded with data, worth perusing. A lot of work went into them but couldn't present them all in the main paper....
Yes we've been patiently waiting for this publication to come out for a long time! We submitted almost a year ago but felt it was important to...
Well adrenaline doesn't create energy, it pushes you to use more though it makes substrates of energy (like glucose and fatty acids) more readily...
[ Through the usual grant process you wouldn't need this outcome measure, though ME/CFS research goes up against cancer and many other...
It's hard to capture a one-size fits all survey I think. I think any development of this type of outcome measure is going to need interviewing...
Excellent post. Thank you. This will help me a lot. I think develop I financial survey will have to be very well-considered. May only...
So would have to capture potential to work, not actual process of being employed.
Double-blinded
Amazing post. Thank you very much for all this information. I think you highlight that it could work at the mild end where people can increase...
Right, for some the improvement might be enough to consider increasing employment. For most, we're likely looking at reduced assistance costs and...
Well the care model for patients we have built up in our head is about energy preservation and we see pacing and medications to help curtail...
I think a financial outcome measure will be important for getting governmental funding support for bigger trials and making a case for future...
Great point and definitely something to consider. We're really trying to transition as much research to the home as possible because of these...
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