Yes during hyperventilation you breathe out more CO2. If TCA cycle is constantly slower then you'd have a mechanism of reduced CO2 production and...
Pathway analyses are a bit clunky. They are simply a guide to suggest that metabolites in this network of pathways are enriched. They help to...
I imagine the cells that are lifelong would be of particular interest in this theory.
I think mitochondria are functioning fine broadly, they are responding to something though. As @DMissa points out, they could be responding to a...
I think the pain aspect with impact on SFN is fascinating and important. Really that's the stand out piece for me. They took IgG from patients...
CO2 is produced from the TCA cycle in mitochondria. It's a byproduct but it plays a lot of important role. Less TCA cycle gets you less CO2....
I guess a good question might be this.. Orthostatic Intolerance can mean many different things. Do ME/CFS patients have more of one type of OI...
Great discussion in here. A lot of focus on oxygen delivery, I think too much focus actually. More interested in CO2 and its impact on blood...
I spoke to Satish Raj about this at a conference. POT doesn't come with the syndrome. It's possible that POT is highlighting tachycardia that can...
We're interested in assessing this questionnaire's ability to assess someone "right now" or "within the last 1-2 day period' as opposed "average...
I think this is an interesting paper. I would be interested in the outcome of this treatment concept as well. Difficult part is working out how to...
ANA levels have been observed to be elevated in ME cohorts on several occasions from memory. It would be good to know if this is a predisposing...
Very true. I meant it in a positive way. I'm typing pretty quickly on here. I can't even think of the right word, it seems like challenging ideas...
Not everyone deals with criticism the same way. Some researchers are unfairly disliked and some are unfairly adored. I think both are the wrong...
Well for research it would be very valuable to have a tool that could predict a patient day. The waking blood samples is fasted and a 24 hour...
Thank you for welcoming here and providing such useful feedback. I agree that patient discussion in project design of inception is really...
We are working with her lab on 2 separate projects on ME/CFS and POTS already. And yes both are looking at PEM so I assume she'd be assessing...
Have you used visible app to predict your day? Does it do a better job than you at predicting your day?
Yeah I'm aware of visible. I think they try estimate capacity in the morning right? Sleep data i think. I'd be looking broad symptom data but it's...
Thank you, we have made a more concerted effort in the space of developing tools needed to improve research on ME/CFS. I think FUNCAP is an...
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