Yes the sham part is difficult, we will be providing some saline. We are also providing 4 different interactions per individual and expect all...
So the infusions are all used in patients already they aren't hypotonic or hypertonic tona degree that would be abnormal. It's dextrose, saline...
They had a mouse for every sample. Makes me think they planned to do one person per mouse but then realised they forgot to account for inter-mouse...
If it is effective then it could be doing many things. We will have a better understanding after the study based on the design. If we wanted to...
You would get much wilder variation in the groups if you did it that way and little chance of statistical significance. Though technically you are...
Not convincing data in ME yet we hope to provide the answers to this question by testing sham, saline, hypotonic saline and hypertonic saline....
Mice vary a lot like people, especially in behavior. So if you are going to use behavioral measurements then you really need 10 or so per IgG...
@butter. This is actually all you need as a summary. I didn't actually add much more. Just that an acute infection control would have been helpful.
The hot plate test shows a difference between Long COVID and acute COVID. Heat intolerance is a sign of dysautonomia. Perhaps anti-M3. Interesting...
That's cool, where is that from? Oh I just saw the embedded link. :thumbsdown:
The controls aren't really there.. would have been nice to see what IgG from healthy with an infection does. Plus the pooling really lowers the...
To be clear, I'm not a fan of mouse work but it can be necessary for answering certain questions on a system level. Ethics is very strict for...
More could be done but it wasn't because it has been very difficult to get funding for animal work in ME. I know people that tried years ago and...
Well I think characterising 500-1000 ME/CFS would give a great overview of the heterogeneity and it would be a target for developing severity...
What differentiates malaise from fatigue to you?
Well one does "sell" the impact of work to get published in a good paper from time to time and to help get future grants/funding, that's probably...
We have a paper submitted to a Nature journal that you will probably be interested in. We're hoping it gets published soon. We looked at common...
You could theoretically do this with early LC for ME/CFS. Sample 500 post-viral COVID (1-3 months) ---- Sample 200 go meet a CCC definition at 6...
There is some effort towards trying to use AI devices to do the thinking for you. I think it's a good angle because this is common of most...
Yes can confirm you do just get in the shower whenever you want when single. When you have multiple small kids you go when you can. When you are...
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