TLDR: considering taking an antiviral taken routinely as PrEP, what do you think about tenofovir for ME, particularly its safety profile? I am...
You can certainly detect significant quantitative differences in expression with this number of samples - it's not like a GWAS as you say. There...
WAVE3 aka WASF3 appears to be predominantly a central nervous system gene. It's expression is mainly found in those tissues according to RNA...
Do you think the female to male sex bias seen in both ME and the majority of autoimmune diseases is suggestive of autoimmune involvement in ME?...
This is great - exactly what i was thinking about. It's quite damning
Thanks, I was trying to find an audiobook version of this yesterday in fact but with no luck. I'll take a look at the text copy instead
I was looking yesterday at a meta review of meta reviews for CBT efficacy in all sorts of conditions, and it found positive evidence of CBT...
Merged thread - article discussed first Abstract here Came across this article in the telegraph reporting CBT and exercise improves fatigue in...
Thank you for the explanations! Do you (Simon, Chris or anyone) know if they reported on rs7337312 ( SLC25A15 ) which looked somewhat promising...
from the body of the paper: "ICP8 was detected in the biopsies of 83.3% (25/30) of Group 1 patients, 73.3% (11/15) of Group 2 patients, and 6.7%...
As an aside I watched the bbc documentary about the novichok poisonings recently and this list of symptoms seemed very familiar! I suppose it's...
The EBV negative MS cases could also either be incorrect MS diagnoses or false negative serology. I don't know what the error rates are for these...
Thanks Andy! This is really helpful. That really is an absolutely shocking paragraph to read.
Signed. What's the nature of this petition? Is it like the German one where reaching the quorum results in some government hearing? Or is it more...
I am extremely worried about the quality of this survey
Question about the PACE trial: It's quoted in Bruce Levin's youtube video (timestamped: [MEDIA]) and in David Tuller's blog that...
That's really interesting. So you might expect protein coding mutations to be fairly binary most of the time - either total loss of function or...
I recall a twitter thread relatively recently discussing a new paper from whole exome sequencing, looking for the contribution of rare variants in...
Something about the hashtag #TeamClots makes me laugh. I think it's that it sounds like they're on the side of the clots rather than against them
This 2010 review ( https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2998922/ ) suggests RBCs use ATP to regulate deformability, becoming more rigid in...
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