This thread's paper also relies heavily on Gene Ontology (GO) term enrichment analysis, which Grimson et al also do. Gene Ontology terms are short...
The Grimson paper is much better powered (n~30 per group I believe compared to n~4 here). The two papers disagree in the abundances of immune...
I believe it was a 2 year gap though that's long enough that the actual relevant series of events could be different to how I perceive them to be....
In Armstrong et al 2015's metabolomics study (n=34 patients n=25 controls) in ME the only significantly elevated metabolite they see in the blood...
Here are some of the pieces of relevant literature that I am aware of: Beentjes and Ponting's recent preprint of blood factors in the UK biobank...
I bought a continuous glucose monitor a while ago thinking it could be interesting to try. @TamaraRC 's post has inspired to me to finally put it...
For me it's as simple as this. When I was moderate but still unable to work/study early in my illness I was mostly sitting. When I'm severe lying...
Great clip really well communicated, which is difficult to do. My only suggestion would be that it's not so much it is/was thought to be...
@TamaraRC you have a slide about glucose tolerance testing on over n=750+ by McGregor. The figure you show appears to talk of small sample sizes n...
@forestglip was 2-hydroxybutyrate significant in that study? Is it possible to get the mann whitney p value for this? I wasn't clear in your post...
2-hydroxybutyrate and cysteine were both elevated in Jason et al 2022's pre-illness data study in ME/CFS: I don't recall seeing it in other...
That's fair enough! I'll make an account in that case
This looks really interesting - no individual TAG passes adjusted p<0.05, but (like with Germain 2020) they all seem to be biased higher in ME....
That's great thank you :) Mann whitney is a safe bet since it doesn't make any assumptions about distribution and simply asks the question of...
For sure, there's evidence that in general serum contains higher levels of many amino acids and differing levels of pyruvate:lactate than plasma -...
This is the CSF data if I recall right? I believe from when I looked at this earlier in the year that the ones in that heatmap are the top results...
Thanks that's interesting. They don't report on triglycerides or phosphatidylcholine in Germain et al 2020 but they do mention they are detectable...
Good point. My hypothetical plot is simply based on the cohen's d effect size value from the raw data, the sample size they report for males and...
High leptin levels seen in this thread's paper in men, was also seen in Hoel et al 2021 [ATTACH]
To compare some of the lipid findings to previous studies that have done lipidomics: This thread's paper describes low levels of...
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