It looks like the protein with the greatest significance for men only is BCHE (adjusted p=0.0003) which is a cholinesterase -...
Fantastic, thank you, that makes sense. : ) In that case I wonder as a suggestion if it might be good to report the units alongside each blood...
I'm not sure I agree with that. I would expect that inactivity and ME/CFS status are particularly confounded more so than the other factors you...
@Chris Ponting Thank you for your answer! [ATTACH] In this extreme example for Chylomicron concentration from fig4A, is it therefore correct...
I'm not totally sure how you're supposed to interpret the results from these direct effect plots: [ATTACH] These are reported as 'effect sizes'...
This looks like a really exciting paper I'm looking forward to properly reading through it. Here is the same table you showed but for the NMR...
As for a preference for amino/fatty acids as substrates for aerobic respiration, this was also argued in Fluge et al 2016: Lower levels of certain...
Reductions in oxygen consumption have been reported in isolated PBMCs. This is what Thomas et al 2020 reported and was the trend reported by...
@butter. sent you a DM :thumbup:
Echoing this thank you everybody for your kind words :) Not for this project. We recruited/collected from Sheffield with our collaborator...
Yes good management of expectations, and as we see it a negative result is also an informative outcome. We deserve to know one way or another....
It was a lot of fun talking with you @Simon M and quite an honour to be featured in your blog! Audrey and I have both been a big fan of your...
I gather there are ways of doing this on genomic data that are not based on related individuals. There's one way that exploits linkage...
1) Thank you! I'm glad you think so :) 2) I think that's basically right, just because the ones they agree on are not significant after multiple...
My understanding is the biggest parameter change is not VO2max, but a reduction in Ventilatory Threshold: The elbow where VCO2 begins to rapidly...
Interesting @Hutan and @SNT Gatchaman. Trying to get my head around what you're both saying correct me if I'm misunderstanding. [O2HbMb]-[HHbMb]...
Thank you :) They didn't do an analysis where they compared multiple datasets (from different papers). I mean that at baseline in their two day...
I've checked here using a linear model whether there is evidence for a given metabolite, that the two studies disagree in their fold change...
This makes sense about the metabolomics done at baseline but I think the two studies Hanson's group did across 4 time points over two CPETs are...
Is this comparing the significant metabolites from at least one study? Or is it comparing all of the detected metabolites regardless of whether...
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