Yes but the crucial thing is that even though I was careful to use ME, CFS, ME/CFS and CFS/ME appropriately in this instance, terms are commonly...
Without getting into a prolonged discussion about various criteria, yes and no. ME/CFS (CCC) does, CFS/ME (NICE) does, ME (ICC) does, SEID (IOM -...
This sort of situation has been playing on my mind. It's tough for us to take the news that the trial was negative but we have to accept the...
152?
@Jonathan Edwards Do you recall saying on PR that Jo Cambridge's team had identified an abnormality in B cells that looked like the opposite of...
[ATTACH] Straw no longer grasped.
I think that I was saved from this fate because I'd been labelled with a psychosomatic illness at 15. In retrospect, I believe it was the early...
I'm not in a position to speculate about the mechanisms but here's my own personal experience for what it's worth. I do identify with a state of...
Yes, there may well have been a placebo effect but there was no placebo. Therefore, the effect can't be determined. That's for future trials. He...
I'm not sure if the trial has been declared null. Marky90 says that "rituximab failed to be clinically effective". Perhaps I'm clutching at straws...
Bottom line is we'll have to wait six or seven months until we find out the true response rate. If there are even just 10% genuine responders,...
Eh, not quite @Woolie I said it more simply, you put it into context.
Yes but that's the nature of self-reports. The phase III rituximab trial also relied on subjective reports but people were generally happy with...
I was just noting the differences in response to a question!
Yes, you're right. The follow up doses were fixed at 500mg, rather than being 500mg/m2 up to a maximum of 1000mg. Also the maintenance period was...
I'm assuming that there will still be responders, the question is how many. What this phase III news means in practical terms is that we'll have...
The primary outcome measure certainly looks very similar to the method they used for the phase II. I'm not (yet) despondent about the news...
He certainly doesn't say 'a distinct disease of its own', that's for sure. Perhaps he means that the symptoms are real in that they are genuinely...
I think that the aim of IiME/UCL was always to identify likely responders. Hopefully, they'll have some great data from Fluge and Mella's trial.
My interpretation? I've no idea. The trial specified primary (and secondary) outcome measures in the protocol. The primary outcome (I think I...
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