“research integrity coordinator” sounds a bit like duty scapegoat, or duty sacrificial lamb.
Well yes, maybe it would not need a standalone trial, but an authoritative assessment of existing evidence. To me it seems that the key thing is...
Is there really no way to prove that ME/CFS is not deconditioning? It's not about us knowing, but about convincing others who still seem to...
I guess you just invented a name for the condition you were suffering from just at that moment ;)
I think the point is that if a study is included in the initial candidate list, then any subsequent exclusion should be in that it does not...
Just to clarify, I'm saying that it's good to assess each facet individually, but that reduced confidence in any one would contribute to a global...
I really do think that risk assessment is flawed if it seeks to evaluate each individual component of a trial as if wholly unaffected by flaws in...
Sums up my very long post in a nutshell.
Been pondering this. When an independent observer reads the finally written up report of a trial, there is only so much they can glean, even...
Exactly. Only shows they are pulling in the same direction, not that the direction is right. ME/CFS research is littered with this. You need an...
Absolutely. Yep!
I'm clearly misunderstanding something then. Because I thought you said that even if a trial is flawed to the degree that its primary outcomes...
What I so very dearly wish for is that the appallingly bad Cochrane reviews of appallingly bad studies on ME/CFS get turned around for the better....
Is there an evidential base for this? Cases where reviews have drawn conclusions from elements retrospectively cherry picked from a seriously...
But unless incredibly careful this could be used to mask the fact a trial failed in its main objectives. Trials can cause great harm if their...
Sometimes humour is the best way to get people to gain insights. If scientists were to appreciate the funny side of these (and many other such)...
Having looked at the Pacing guide, I would just comment that the objective stated for pacing will likely vary from person to person, both in terms...
Yes! We have to be very careful to not conflate "self reported outcomes" with "subjective outcomes"; although closely related they are not the...
Absolutely. I was going to pick up on the same thing. If a source of bias exists then it exists, and no amount of arguing other points will...
But surely @Snow Leopard's first point is true - referring as it does specifically to response bias and related distortions. There was no...
Separate names with a comma.
