Exactly i.e. "NICE are supposed to make use of the people who know how to do it, surely". OK if it's difficult to get hold of the experts,...
Re "IDO inhibition", from memory Robert Phair* mentioned that there was a trial of a drug which inhibited IDO1 i.e. in people who were terminally...
Thank you very much for your insight @Snow Leopard.
Yip interesting to know if this is relevant to ME or could be. @Jonathan Edwards post re immune dysregulation(?) here, came to mind:...
It seems like the best you could do is arrive at some sort of basic rules re what is acceptable/unacceptable e.g. @Simon M had a basic (but sound)...
I wonder if they even used a good reference method for B12 deficiency (i.e. methyl malonic acid). Also, did they try the technique @Jonathan...
Pray what are these "specialist clinics were genuinely excellent" dispensing and has it been validated [and not by GRADE]? Or is it just the fine...
I think the problem with GRADE is that it's not that easy to define the dependent variables i.e. measure X, Y, Z --- and if the study is flawed...
They might have wanted to show they had looked at all of the crap - even if you're correct i.e. they should have said it's crap and here's why---...
Well to be fair, if you were in NICE, and you had to answer for the mess, then it would be reasonable to ask for the money to do the job properly.
I used to drink wine and relied on XYZ--- to guide my (cheap) choices NICE should be able to evaluate evidence and, as @Jonathan Edwards points...
As I've pointed out before I haven't followed this carefully. Let's say @Jonathan Edwards has done a study in rheumatoid arthritis using...
Yes the "beauty" of what they do is note the remarkable consistency of studies which do not have objective outcome measures, and are unblinded, --...
Yea surely a medical Doctor who is unsure of a diagnosis can set out their views and ask a colleague(s) for their views? Black boxes (like GRADE)...
It may not be that different from the Hawthorne effect https://en.wikipedia.org/wiki/Hawthorne_effect indeed @Jonathan Edwards advice that he...
I assume he's a medical Doctor in which case he's disowned his training. If 100 people get I'll and 90 recover - the reasons the others don't...
If the "retired believers" are those who spent their "professional/work" life in this then they presumably have a vested interested in believing...
Never used a chiropractor but they have a reputation - not a validated part of medicine - very lucrative ---- seems like there's a theme here ----...
I live in Northern Ireland [UK devolved administration] and vaguely recall having a brief exchange with the Health Committee i.e. re NICE...
The cost of going to Court alone should force a rethink - at a wild guess I can't imagine it would be less than £100K. Not sure there's anyone in...
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