I think Sid is right here. An 'antibody level' to a protein measured in a particular test is really no more use than an antibody level to a...
Not a lot other than it was suggested that there is way of knowing what is cause and what is effect when it comes to the mitochondrial side of things.
Making a hole in somebody's breast bone is not trivial so before doing a bone marrow one really needs to have some idea what one might be looking...
I am afraid that immunoperoxidase staining of that pattern with a monoclonal antibody can mean almost anything, or nothing. Gut tissue is the...
That is not the interpretation an eminent mitochondrial expert gave me by email!
Which just shows what garbage diagnostic criteria by committee are!
It seems to me that putting PEM in the title begs an awful lot of questions. I have clearly had some form of 'Long Covid' and I got exhausted...
Bone marrow sampling has a reputation for being one of the most painful procedures in medicine. It need not be too bad but it is not something to...
Maybe not but the title says that muscle abnormalities 'worsen after PEM' (unspecified). I think researchers should be more careful about the way...
Maybe, but the poetinsf's point remains I think. Also, the CPET studies suggest some general metabolic shift after exercise, which might tie to...
I agree. I don't see how these findings can be taken as 'accounting for PEM'.
I am not sure it fits with anything very specifically. I suspect that the signal would be 'pleiotropic' or in other words would do all sorts of...
I think the relevance may be that we would not expect B cells to have problems with energy production relating to circulatory/vascular or...
It suggests that something is pushing lymphocytes towards a different pattern of metabolism. That could be a signal that is also making PWME feel...
Useful to see that. I think more than anything it emphasises the sampling problems likely to play a big part in the results. Measures that jump...
The change looks pretty big to me - maybe a doubling in at least a good number of the higher scoring samples. This is new 'deposits' appearing...
Indeed, but I worry that the interpretation of this recent paper supports that view - it suggests that PEM is all about inflamed muscle. My...
I think we have to ask whether these are in fact 'amyloid deposits' or at least in what sense. Note: 1. we have no evidence of any amyloid...
If you had significant impaction on the spinal cord from CCI you would almost certainly have 'chronic fatigue' just from that. Spastic weakness in...
This study is describing findings on people with the standard indications for surgery for CCI whatever the background cause - severe pain,...
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