Having a quick look this seems to be mega-quackery so we can bin it. I liked the sentence that sums up their results We have seen numerous...
Qeios is actually a very good idea in that it is free access, referees have to give their names and authors can respond as many times as they...
The poor lady seems very confused. How could unconsciousness be psychologically driven if the mind is turned off (unconscious). She doesn't mean...
Sure, but diagnosis has to depend on symptoms that discriminate between one diagnosis and another and that often has nothing to do with what the...
As far as I now it is not based on any reliable evidence. An abstract that makes unfounded statements like this is not what we need.
Very Guardianny article about listening to patients...
It's actually a very clever question. I am not sure that anyone has asked it and it makes sense. Allergies depend on IgE committed B cells and...
I don't know but I can see how it might come about. Young people with autoimmune disease present a particularly tragic scenario - often unable...
The resistance of antibodies to nuclear protein antigens (Sm, RNP, SSA/B/Ro/La) to B cell depletion was identified by Maria Leandro in our first...
That is one possible theory but the very first patient with RA treated with rituximab indicated that the situation is more complex. Her B cells...
This is exactly the way the 'molecular mimicry' theory of autoimmunity works (or doesn't). The joker in the pack theory. The theory says: 1. The...
It's a bit more complicated. Rituximab depletes CD19+ cells because CD19 and CD20 are largely expressed on the same population but that is B...
I do not claim to fully understand the complexities of the genetics. However, as Simon describes, this project seems to be a collaboration that...
That makes sense. Though I would be doubtful that anyone can yet make definitive statements about Sjogren's which is a nightmare of a clinical...
The point I was making is that both rituximab and CAR-T therapy target B cells rather than plasma cells - either via CD20 or CD19. CD19 antibodies...
The most obvious difference seems to be in the bones (presumably marrow). So whatever the difference means, if it is real, it isn't particularly...
No, I am afraid not. CAR-T therapy does the same as rituximab. The only difference is that you may not need to repeat it. If CAR-T was going to...
Maybe at last we have what I was hoping for twenty five years ago - a powerful enough B cell depletion therapy to produce long term cure. If so, I...
I suspect this is wishful thinking. Not long ago the antigen in MS was supposed to be something else. I doubt it has anything to do with cross...
blurgh...
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