Definitely is interesting, though I do worry when a scientist seeks to patent something like this, presumably for their own future financial gain,...
Just being devil's advocate. How much was donated to the Clare Francis Research Fund? "research-related activity" is presumably a superset of...
This would not surprise me. Thinking about my wife (who is mild / moderate), her 'fatigue' is a key limiting factor, and if she were able to...
Another thought for the mix. Subjective questionnaires are going to result in pretty inconsistent answers even for people who are cognitively A1....
I doubt this would necessarily cast doubt on the possibility that ME could be a problem in the mitochondria, though of course that is itself very...
Basically the readings are susceptible to a lot of 'noise' and the the notional minimal clinical difference values are completely lost within the...
And I'm sure I recall a PACE participant saying they did their 6mwt by 'exchanging' it for some of their otherwise normal activities. Even...
Yes, I've noticed there are some member tags that do not auto-complete or come up in a search, yet seem to still be valid members nonetheless....
Does this also touch on the issue of Control, within and across trials? Presumably you could have several trials, each of them a properly...
Yes!
https://www.sciencemediacentre.org/wp-content/uploads/2019/10/Advice-for-Researchers-Experiencing-Harrasment-2019.pdf
What evidence is there that it is normal? Given how subjective it is, how can we know how the scores correlate with actual fatigue?
Yes, I see what you mean. The divergence of the PACE data from a normal distribution will be significantly influenced by the non-linearity of the...
Yes. I cannot claim to follow all this by any means. But any analysis inevitably has to make certain assumptions about the data being analysed,...
The leaflet has one overriding omission: Are those objecting to your research right? Are their objections scientifically sound. They seem to...
Yes. How are you now, compared to before you got ME? "I feel terrible." ... some weeks later ... How are you now, compared to when you last...
Yes @JaimeS. This is what my (somewhat rambling) post here was getting at. As we know, PACE a la GET was in no way seeking to trial a hypothesis...
Indirectness of evidence. Yes, this makes excellent sense to me. Investigators using evidence n-levels removed from directly-relevant evidence,...
NAAFI tea was (and probably still is) a stalwart. Tea would go into a huge pot at the start of the day. Throughout the day it would be topped up...
I like my tea strong ... but not that strong!
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