And a (time-limited) link to the published version of this blog is here: https://authors.elsevier.com/a/1fFlT_KDvPN8-W
I asked Douglas Kell about this striking elevated level of % Area Amyloid for type 2 diabetes (relative to controls). He agreed that they had seen...
Hi Jonathan. I asked Doug Kell about this specifically, and he said that the experimentalists were blinded to case/control status.
Joshua, Simon and I also wrote a slightly more accessible version which is available here:...
There are so many people who made today's announcement the success that it has been, esp @Andy @Simon M Sonya, the charities, the funders and our...
Thanks. I don't think this was replicated by Jackie Cliff et al. : https://www.frontiersin.org/articles/10.3389/fimmu.2019.00796/full
The Editor would request proof that these SNPs are not associated. Trying to prove a negative is a fool's errand! I do hope that the MEBiomed...
An infectious onset is not reported for this UK Biobank cohort. Nevertheless, I would expect these SNPs to skew towards zero. But they do not....
Can these SNPs be replicated? The answer is "no". I went back to the UK Biobank CFS findings (far more than 305 ME/CFS patients) and asked what is...
comment copied from Genome-wide association study thread Small study, but great to see a genetic signal. This needs replication and more samples,...
Small study, but great to see a genetic signal. This needs replication and more samples, but at the moment this does point towards an adaptive...
Yes, this is true. I am hoping (not expecting!) that the GWAS is funded and that a funded PhD student picks the study. If the GWAS is not funded...
Thanks. What other optional questionnaires would you like to see? SF-36, for example? Yes, we need to ensure that the questionnaire load for a...
If there is a compelling argument for such a trial (passed by an ethics committee) then eventually yes, but more likely (and sooner) we expect...
Yes, the idea is that the 20,000 cohort would be recontactable for further questionnaires and studies - no obligation to participate! All data...
Thank you all for this fantastic feedback - keep it coming. I really like the way that the conversations we've been having recently within the...
Thanks for this. Just to mention that the MRC's emphasis on a GWAS is not new, and goes back to their Strategy Board's comments (25 March 2019)...
Hi. For information, I had only a minor role in MEGA. There were no posts and no funds proposed to come to my team. I wasn't down to do the GWAS -...
Thank you so much for your comments. As to your last comment/question, the MRC and NIHR are very serious that pwME/patients are front-and-centre...
Interesting! I met with a PR agency last week and they said that the greatest impact would come from telling the stories of people with ME. Far...
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