Yes, we will take care to investigate age-related stratification, particularly because our primary cohort (UK Biobank) is of older folk. One of...
We are going to look computationally to see whether genetic signals for diagnosed ME/CFS are shared with those for other traits using LD score...
"the study wants to study every single person with ME/CFS in the UK above 18". I like this idea! Thanks.
Yes, this is correct. Initially, for controls we will use the 500,000-strong UK Biobank study (not to be confused with the ME Biobank at the LSHTM).
Yes, we are going to ask participants to consent to be recalled into new studies. This provides the exciting prospect of "recall-by-genotype"...
One of our inspirations is the “snowball sampling” spit-and-post approach of Genes for Good project (https://genesforgood.sph.umich.edu/) in the...
Thanks. Yes, we've been discussing a multi-stage process, with the first step being in the UK. Standard GWAS analysis takes account of population...
When we discussed this as a team, we thought that the only limit (because of consent issues) was the lower limit of 18 years, but we were not...
Thanks. The reason that it doesn't show up in the UK Biobank (UKBB) is that this UKBB project was not focused on a particular disease (e.g....
This is not a Genome-Wide Association Study (GWAS). It is not genome-wide, it has no appropriate control group, it is not well-powered for its...
Sorry, hadn't seen this until now. I agree with you, re: P4HA1. About chromosome 1 and LPGAT1: There is a risk of reading too much into 'peaks'...
Yes, the statistically significant association is to the DNA variant (SNP) and not to the gene. But having said that, the DNA variant does also...
Whole genome genotyping, probably using the Affymetrix UK Biobank Axiom® array. This will survey ~850,000 DNA variants in every person. Yes, it...
Unfortunately not likely. Participants were chosen according to different diagnoses, but I think it's highly unlikely that pwME were included....
Thanks. A q-value is the expected fraction of 'false discoveries' in the full set of statistical tests used....
@RDP It might be interesting to apply for the 50k exomes' data from UK Biobank. ~200 people with self-reported ME/CFS are expected to have had...
Thank you @RDP. This is very helpful indeed. I am only now left with a couple of questions: (1) What is the probability that your analysis would...
RE: "So if it is only two individuals that have this MNV I think we can say that for most people the STOP is valid. Am I right?" Yes, you're...
Great questions. (1) Until the experiment is done we will not know for sure. But because natural selection is good at weeding out "bad" mutations...
Thanks. If we think - conservatively - that half of this cohort of people have one disease (with a genetic contribution) and the other half has...
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