Very few. MAF = minor allele frequency = 0.0001062. This number times 450247 is ~47 who would have *one* of their two copies of this gene with...
I needed some time to look into this. By reading the Broad investigators' manuscript on MNVs (here:...
There are mutations in the protein-coding parts of IDO2. You can see what and where they are here:...
Sorry: the y-axis is the negative logarithm (base 10) of the p-value. In other words if p=0.01 then -log10p is 2; if p=0.0001, it is 4; etc....
The UK Biobank results were generated entirely blinded without prejudice with respect to genes or traits/diseases. It was designed to determine...
"Deemed significant" - this is the conventional genome-wide threshold, i.e. an industry standard. See https://www.ncbi.nlm.nih.gov/pubmed/30349118...
Just read the genetics part of this paper (https://www.mdpi.com/2075-4418/9/3/82/htm) and because Kashi et al. propose that "any predisposing...
Yes, there are tests for the burden of rare variants, for example: (1) https://www.cell.com/ajhg/fulltext/S0002-9297(08)00408-4 (2)...
I'd need to read the methods describing the approach taken before I can come to a view. But I think what was being said was that a GWAS would...
Yes, my main concern is meeting this target. One thing that I need to find out is what are the restrictions from recruiting from outside the UK....
Hi Robert. Yes, absolutely correct. Because the trigger (the pathogen) is not "written into" the DNA of individuals, we would not "see it". But...
Sorry, I've been away on vacation and so have not been following these discussions. Simon FWIW I think you've done an excellent job of explaining...
I just wanted to highlight a paper that came out today in Nature Genetics: Lakhani et al. (“Repurposing large health insurance claims data to...
Sorry for not explaining. I think the question is: "Is the DNA variation in IDO2 unusual?" To me here 'unusual' means compared to all 20,000 genes...
Interesting. There are 174 different missense and loss-of-function alleles for IDO2 listed in EXAC, so the multiple testing correction really...
Thank you. Yes, absolutely, the opportunities to invest are not new. Evidence in person, in meetings and on paper has been presented and - yes -...
I think only the videos are being posted this year. There was a low download rate of other materials from previous years. That's what I am told.
My apologies - I had to run for a plane so had to make the closing remarks brief. What I could (should?) have said is that there is a narrow...
All good points. A single, non-replicated, GWAS finding is not sufficient - I agree. This is why my personal point of view is that a well-powered...
Thank you for your generous comments and offer. Most science grants are for hundreds of thousands, if not millions, of pounds. For this, the...
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