The brain isn't entangled. Neural events are classically determinate and it is their independence, or lack of correlation, that gives them...
I think there is a major problem with the method of recruitment in this study - making it self fulfilling. No doubt people with Long Covid have...
On what basis do you say that? Was there any analysis of hypermobility in the study? Edit: the word hypermobility does not appear in the paper....
Well, since nobody has an understanding of the illness, and least of all psychologists who have no idea how to evaluate evidence (and apparently...
It is as we found it - slow to fall if at all, although those with lower levels did get a drop. I am not sure this is interpretable at 3 months...
In very simple terms linear processes are those in which what you get out is proportional to what you put in, without any feedback or interaction...
No, I agree. It is just that 95% of people in the field still seem to have a belief in mysterious auto reactive T cells driving the autoantibodies...
No, the autoantibodies are made by the B cell clones they think they have killed, or at least their plasma cell offspring. So that would not be...
Furthermore, generalizability of the CD19-targeted CAR T cell approach to other autoimmune diseases is unclear. Again, yes, as we have said...
In the two patients with the longest follow-up, seroconversion of antinuclear antibodies was observed, indicating that abrogation of autoimmune B...
None of the traditional immunosuppressives mentioned have the sort of effect B cell depletion gives (i.e. as quoted in the above post). Belimumab...
Yes, we knew about that before we started with RA in 1998. Rituximab does not clear follicular B cells. But I am not clear that we have evidence...
Huge if it pans out. The findings so far are not really different from ours in 2000. The reported follow up of three months for some of the cases...
Almost all B cell based autoimmune diseases are more common in women. Differences in antibody production between males and females make sense...
Yes, it is exciting. But remember that Leandro, Edwards et al., in around 2000, reported a similar series (actually a bigger one) of SLE patients...
I am not sure how well your diagram illustrates the maths behind the problem intuitively, @Simon M. It is hard to think of a way to do it but what...
This is just wrong. Forget it. God knows how the publication system has come to the point where this is considered publishable. There is no...
I am afraid to say that I do not get that at all. Patients mostly grab on to ideas because they are oversold by researchers who have hyped weak...
I don't actually understand the justification for making meetings closed. I have never seen a need. The impression given is that the reason for...
Actually the situation is more complicated, @Pibee. The first trial in SLE was done by Maria Leandro and myself and it was clear that major...
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