ME. post viral incl long covid, in some respects sarcoidosis - immune derailments. 1 Garner - strong chassis, derailed, short sharp reset on rails...
As far as I know no. I am in the anything that helps camp, but I share any concerns about trumpeting sth as science which is not. about absolute...
There was a guy in South Africa , Nash Petrovic, who supplied tailored antioxidant and other supps and had some successes among ME diagnosed. Of...
I noticed that the group had used the term PEM when what had been found could have been referred to as exercise intolerance which is found in many...
Would you say that there is also the question of when/whether "circuitry" disorders step in, where the system just responds...
Yes, it could be that some have an immediate response, which might be different from a delayed one but that the delayed one then piles in. The...
You've read it in more detail that I have. Was it the mt impairments that caused the o2 uptake probs, vice versa, bidirectional or unrelated...
I respect your experience and small studies, cohort issues etc will dog the debate. But on the subject of low O2 uptake I read around and found...
Maybe all kind of things going on to different degrees in different people and all united in "Betrayal by the Brain" as Jay Goldstein said. The...
Are you aware of Cara Thomas work which showed poor o2 uptake in peripheral MBC? She found normal mitochondria in her group but some probs in...
Not necessarily relevant but just to chip in acute sarcoidosis has been found to show elevated ox phos while chronic sarcoid shows reduced ox...
I have had and may still have raised gene expression for Ifn gamma and TNF alpha. My thinking has been that these may corrupt control mechanisms...
The paper on GWS uses "dysfunction", but the specific nature of ME PEM is not maintained in that term. Hard to know what else to use than malaise etc.
Agreed re. what the reported problem is but you did veer imo into an implication that fatigue is not in itself pathological, when it may be. When...
Exercise alters brain activation in Gulf War Illness and Myalgic Encephalomyelitis/Chronic Fatigue Syndrome | Brain Communications | Oxford...
There is no categorical tiredness vs illness dichotomy. What about pathological tiredness? Depression is not the same as sadness but malignant or...
Could be both. Engine problems, pilot keeps flying, enginen gets worse (potentially), pilot gets tired/overwrought. Two systems one flight experience.
Thanks for the clarification though I am not sure I have understood and I am surprised that nothing has been found over such a range of systems....
Maybe a division can be made between PEM with explanations along your lines and other exertion intolerance where such things as muscle probs from...
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