Well IASO Bio also has such graphs with even more clear IgG to near 0, with only BCMA. But in their recent paper they mentioned something like...
Hmm IgG went to "0" very fast so seems it can't be late plasma cells dying?! Most patients were on 5g IVIG [IMG]
From the recent report with dual BCMA CD19 [IMG] Why would anti-SSA persist until 100+ days and then rapidly fall, what would be the explanation...
A study with dual CD19-BCMA CAR-T, for 13 SLE patients is published, with up to 46 months of follow-up. All patients are in remission besides P11...
Yes, so in any case it is not likely because as the authors stated because of CAR-T cells persistence or prolonged nycophenolate?!
@Jonathan Edwards so do you think that the persistence of CAR-T cells for 11 months (vs. average 3) is responsible for the complete disappearance...
Do you know about anti-ku? A person I know is doing CAR-T with anti-ku. He has myositis & SLE. low anti-dsdna. But he goes for CAR-T mostly for...
Dual is the best but perhaps too aggressive & only BCMA has good results too but its all up to 2 years follow up so might be too optimistic to say...
I have heard of mostly relapses/failures of treatments w CD19 when Sjogrens is also present (usually with neuro illnesses) so i'm glad to skip...
a SLE patient with RA is in remission of RA from cd19. I think the same patient has SSA, not sure..and had a flare up of nephritis so you can...
I tested 3x over the reference range for anti-smith in 2023, now it was negative. I bet they didn't even test ENAs after ANA 1:80, just wrote its...
seems CD19 wont be enough for MS, ... at least based on OCB just dropping in 1 patient and persisting in other, that's discouraging. It might...
No, I haven't heard anything for Graves, except maybe running into the same study you shared here. It seems definitely far from happening for...
I know CAR-T aimed at B-cells for antigens of MusK and DSG3-CAART for pemphigus vugaris, failed, with or without chemo preconditioning. Do you...
It will be soon 3 years for the first [German] patient (it was done 1+ years earlier in China and because they used CD19-BCMA they have even...
I never expected that I, as a MECFS/Sjogrens/POTS/SFN person can be cured by CD19 alone, I feared for 2 yrs it will require BCMA. Seems Chinese...
https://pubmed.ncbi.nlm.nih.gov/37147113/ Abstract Objective: Identify autoantibodies in anti-Ro/SS-A negative primary Sjögren's syndrome (SS)....
Just to make it a bit more clear that the seronegative Sjogrens (no SSA) is not a made-up thing by private physicians, but it is included in the...
yeah very impressive. Just afraid if anti-BCMA would make relapse earlier than when also CD19 used, and if we need both
I am not diagnosed by private physicians, I am diagnosed in a University hospital with a lip biopsy They don't need to change the definition of...
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