If you mean the unblinded continuation study following the blinded phase 2 ME study then I don't think it would get as far as being assessed by...
I think thesis great, because we have Gordon Guyatt, Mr GRADE himself, weighing in and saying his system would have rated PACE as reliable...
As I said before I am not sure I have much more to add, but the situation is complicated. Steroids give people a high so the fact that trials...
Yes, since the eighties is the new way for me!
The whole discussion is surreal. As I understand it, although I admit to being confused by the complexity: Turner Stokes and Wade said that NICE...
GRADE works like this. You take a group of people who think that they have a reasonably good appreciation of the risks of methodology being faulty...
It's OK, that's because they don't either.
I think it may be that UK ME patients have managed to find these people out. The hatred reflects a fear that a meal ticket lovingly polished for...
I don't think anything will actually be done.This is just a soundbite. If anything is done it will be the same as for ME - trials of exercise,...
I have just read the comment from GRADE - it is wonderful - it reveals just how little they understand about anything.
I think this was fully expected @Esther12 but it gives us an opportunity to push back on GRADE.I have in mind a formal publication about it once...
Surely the stigmatisation derives from calling it4 persistent somatic symptoms. If you simply say that someone had Covid and, like a number of...
I said like CRP - there are lots of others that are also missing. If the Nakatomi study is replicated that would be very interesting but it is a...
On the other hand I find it extraordinarily difficult to understand why anyone without a commercial motivation would bother to test a drug so...
Out of patent then?
Whether or not the authors have got input from people with some understanding the authors themselves clearly have none. To mix health care worker...
But we don't have evidence of inflammation in ME/CFS. If Syk kinase was involved I think one would expect some evidence of immune activation like...
I suspect that dexamethasone completely covers these targets. I cannot see any need to look for more vaguely a bit sort of anti-inflammatoryish drugs.
I agree. In terms of being relevant to disease causation those graphs show unequivocally the the differences in antibody levels are not relevant....
I would go for ibuprofen, certainly.
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