I was not talking about members of the profession with no dealings with ME/CFS - we know those are ignorant. I have spent the last few months...
The studies so far show an apparent difference but answering the question about how these findings relate to a mechanism that might make them more...
My comment was intended to indicate that I worry when people start talking of 'nearly 100%' as if 100% were something to aim for. Almost all...
Jen, please stop putting out statements that you are not qualified to make. It is accepted by the vast majority of medical practitioners who have...
clinically and cost-effective treatments If I am not mistaken it is a direct quote from the NICE protocol for its guidelines - in which case...
It is worth remembering that a test with 100% sensitivity and specificity is useless, because it recognises a group that you have already...
Seems very fence sitting to me. The metaBlind paper is based on too poor a methodology to be worth considering or repeating in my view and Bastian...
I invented the dosing regimens for autoimmunity and I am pretty sure dosage doesn't matter very much at all. We probably give twice as much as...
I think he was but I was surprised even then that he seemed to be taking the thing seriously to some extent.
I find this quite distressing to see Dr van Elzakker apparently giving credence to this surgery. There is no science here. There are no proper...
Yes, an individual case is hard to make much of. It is the recurrent patterns that I think are more informative. The time course of change after...
That was the phase 3 trial, Adam. I was using the unblinded continuation of phase 2 as an indicator of a placebo response. There are no controls n...
I disagree. I am talking about whether or not we can make valid distinctions on a very pragmatic level. I don't think so. To me feeling optimistic...
Yes that was the conclusion I put in my report to NICE. And not very surprising I would have thought. If CBT had been delivered universally by...
The trouble is that I don't think there is any way to validate that distinction. There is no 'god's eye view' of how healthy someone actually is...
I think we have to take into account the fact that with repeated rituximab infusions a number of patients had saw tooth 'response' charts...
I don't follow that. If they thought they were better, and that this was due to a drug, then that counts as a placebo effect, doesn't it? I would...
Reporting bias is theoretically possible but having looked at the data I find it very hard to believe that in these cases people did not think...
I can only be a genuine ally of PWME if I stick to the truth and all possibilities that need exploring. Medical science does not allow us to...
How can anyone tell? If we have strongly suggestive evidence of a long lasting placebo response in some cases then it has to be on the cards.
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