We have not eliminated B cell autoimmunity but I agree that it is not looking very likely. T cell autoimmunity does not exist very much as far as...
Yes. Whereas most autoimmune diseases work through one or two linked antibodies lupus has a whole family of autoantibodies. The central ones are...
Not like ME at all. There is well established pathology. There are pretty reliable blood tests. And there are very effective treatments for a lot...
I think this is right. Researchers cannot go searching through records of people who have not volunteered.
I hate to say this but you are asking for medical advice. I could give all sorts of rules of thumb but they are all easily enough misinterpreted....
Animalmodelobabble I think.
0.2% of 60million makes 120,000 to me. That is based on diagnosed cases. No doubt there will be more undiagnosed cases but goodness knows how many.
I think it would be pretty unlikely. If a signal came up in one population another population with a Biobank would certainly be a good place to...
It slightly surprised me at the time but I have a pretty clear recollection of it. Somebody will remember. I think it was the prevalence study...
I forget but I think Lenny Jason was involved. There was a US study that showed that something like 80% of people who had been diagnosed with ME...
Yes, the controls are already fixed and that is why it is so crucial to recruit from a matched population.
You don't get a signal linked to being English if you control within an English population. Anything linked to being English cancels out. The...
No, that would be a disaster because it would bring in all sorts of genetic association from friends and relations. Studies like this have to be...
If I remember rightly the US study that looked at ME/CFS diagnosis by physician indicated that physicians over diagnose ME/CFS by about five fold....
From my perspective this would be an extremely bad idea. If I were reviewing the grant proposal I would not be happy with bringing in an unknown...
This may have been covered but when asking people to show interest is there a box for saying how they came to know about the project. It is always...
I have not looked at the stud details thoroughly but I wonder if there may be some selection bias in the finding of a difference between ME...
I think the preferred estimate is 0.2%, which would be 120,000 and that figure comes from diagnosed cases, not from trawling around finding...
These look like phoney commercial set ups peddling pseudoscience. Do we really want our research to involve such outfits?
That is an interesting way of trying to gauge the minimum number of people who are aware of online material on ME. I say minimum in that if...
Separate names with a comma.
