T cells do gradually reappear, over many months and years. Whether or not they are less problematic I am unclear. Most of the T cell theorising...
I think this reflects three things: 1. Lemtrada is not actually that good an idea for MS, either theoretically or on evidence base of...
It isn't. It is just that we make a billion new B cells every day but after twenty hardly any new T cells. So B cell depletion lasts for as long...
I find it very difficult to take the data at face value. The groups seem to be tiny yet standard error bars are tiny. I have no idea what the...
I absolutely agree on the multi pronged approach - which is why I said 'rely on'. I am sure some patient can be found through clinics, GPs and...
All you need is to be an occupational therapist and have poor skills in the English language: I have had an unusual trajectory into science. My...
Not published responses - just to me. There is no peer review. The sort of stuff I put there does not really lend itself to the sort of peer...
I ask my departmental IT person to upload a PDF to my page on the College site. It has a URL then and I can cite that in other papers and do, as...
This is called crying wolf. Publishing costs nothing. I regularly publish stuff for nothing. Google picks the articles up within a week or so....
Campath must be out of patent now. There are companies doing generics of most these monoclonals.
I am more optimistic. I don't see any real need to rely on recruiting through doctors or patient organisations. All of us know of a few hundred...
This seems an important point. However, I am fairly confident that the political concerns involved are only in focus for a rather small number of...
I don't know of any evidence of T cell exhaustion. Almost total depletion of T cells with Campath for several years produced nothing much in the...
That dialogue worries me a bit since the question posed by qua sar doesn't make much immunological sense. T cells are not involved in the removal...
I saw the site you posted on this. This is some sort of swindle set up by the drug company, which does not surprise me unfortunately. The...
I am afraid that complex patient more or less means 'difficult' in the sense that a child can be difficult. There are other contexts where complex...
If there was good evidence for it being a sensible thing to use the cost would not be a big issue. It is similar to rituxmab and we have already...
No it just means I was teasing.
Not sure what you are referring to exactly. So far we have not been told what the findings are. MAIT cells did not exist 20 years ago. But it is...
I think alemtuzumab is the post-hoc generic name for the same antibody that started out as Campath. It targets CD52 which is on all lymphocytes...
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