Very good question. I don't know either. Maybe I will have time to look at the methodology in more detail later but often in these studies it is...
That is why I think a dose response study is the only way. In pharmacological clinical trials you do not get taken seriously unless you have dose...
No, absolutely not. The point is more subtle: the term 'encephalomyelitis' was used in reference to the Royal Free outbreak because physicians...
Yes, but he would have meant absence of physical signs as well. Assuming he was a diligent neurologist he would not have called someone with...
This. The problems in the past were of the sort that, as my old boss used to say, even a policeman could recognise.
But at least at first pass it looks as if oral is as good as IV, which makes sense and would save a lot of wasted time and money.
I actually think is needed is a dose response study. In a dose response study patients have no idea whether or not the dose they get is likely to...
It is interesting to hear Behan make the slightly surprising statement that these patients were all completely healthy and yet were fatigued. I...
I would like to think that too. But it seems that you and I have been wasting our time because none of the people we have been talking to have ME...
I think the illness people have now is probably the same as or similar to the long term illness Ramsay described. I think the initial acute...
I didn't see a dummy control though? There ought to be a double blind arm where there was only dummy fluid replacement, or probably better a dose...
I think it would be counterproductive to try to engage with comments on Virology blog. The place for rational discussion is here, I think. The...
It didn't seem like subgroups to me - more that CFS is not ME.
It is not clear from the text to me. They say that physical activity leads to increased GDF-15 levels suggesting that activity puts it up. So...
Could you expand on that @Caroline Struthers ? Bero raises what I think is a really important issue. Declaration of interest requirements are now...
Yes, I have looked through them. I am happy to listen to every view but I have not so far changed my own.
I can well believe this is the experience in the US. My only contact with a service rheumatology clinic in the US gave me the impression that I...
I have not read through but this sounds symptomatic of something to steer very clear of - the message that 'those experts know all about ME/CFS...
I think I have probably said enough on this topic. it has been helpful to go into more detail in discussion but I find that everything points to a...
That looks like a speculative review in a throwaway journal. The abstract is typical of the sort of word salad you get with reviews these days....
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