Like you, I think the risk of picking up wrong signals is more of a problem than missing because of dilution. However, in that case the higher the...
I am not worried about some dilution of the cohort with misdiagnoses. If 60% of the 20,000 ME/CFS cohort did not in fact have ME/CFS, maybe not...
I think it may matter because the normal genetic spread of different age groups may differ because of differential birth rates and migration. I am...
Yes, but in a sense they have to cover those in order to say anything sensible about referral. The GP accesses the software to decide who to send...
It looks as if Health Pathways is chiefly about referral to other health professionals from primary care. NICE guidelines are about what sorts...
I am not sure where over here is but I would agree that within the medical and scientific research community internationally the distinction...
If neurosurgeons treating EDS actually have evidence for things like this then they should publish it. The most recent review by Henderson,...
As I understand it the healthy controls are already sorted - hundreds of thousands of them. But they are from a UK population so the patients...
In fact the larger the sample size the worse the problem for systematic bias. The effect of sample size is quite different in that respect to the...
I shall be involved as an advisor. My view would be that it would be a serious mistake to try to extend recruitment beyond the UK at least for an...
That is why it would be telling to include the MRIs of those who have had surgery. And if a high proportion of MRI scans are reported as showing...
Not necessarily. It would probably be quite easy to break down the effects of traction into different components - restriction of rotation,...
You could add in to that the (blinded) MRIs of all the people who have had surgery so far.
Surgical trials can be blinded using sham procedures. That has practical difficulties and major ethical difficulties but it has been done in the...
I agree.
My information is that the Biobank team have found some differences in mucosa-associated invariant T cells (MAIT) but not T regs.
Another relevant point is that drugs require licensing, Operations do not. Irresponsible use of surgery is 100 times easier than irresponsible use...
It may be worth pondering that there are good reasons for thinking that certain physicians in California are involved in both the off label use of...
I am sure you can get scalpels and forceps on line too - it is exactly the same. All the people who accessed rituximab did so through a medical...
How is a doctor prescribing any different from a surgeon operating? Both involve a medical decision not based on good evidence. Before the...
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