So what are the statistical chances of more than one person in the trial having undiagnosed PA? I am sorry but, like most studies of...
There is also the puzzle that the responders already had higher B12 levels at the start. Maybe they 'responded' because they were into vitamins...
I think an important point of the Nacul study was that definition of ME is so uncertain that you have a tenfold range of possible prevalence and...
I suspect the non-responders could not cope as well with the faff of going on sticking stuff in their nose and were non-responders because they...
According to the abstract B12 increased significantly in both groups.
In the non-responders, only a small but significant increase in vitamin B12 levels was observed. In contrast, in responders, the number of steps,...
This struck me hard in the context of the NICE committee. The answer to the criticism of PACE from the therapists is that they do not do the...
Dear @phil_in_bristol, I understand your commitment and desire to help. However, 'it wouldn't look good' is never a reason to misinform is it?...
That abstract sounds to me like a misunderstanding of statistics. I d not see what it means to be statistically confident of a change in an...
I have come to think of the GRADE handbook as inexpert opinion!
Actual usefulness is what clinical usefulness means. Clinical usefulness means relevant the patient rather than a lab or pathology specimen or...
I agree with Alex.
I don't actually think statistics come in to the concept of a clinically useful difference. A clinically useful difference is defined by clinical...
I don't think that is right. 'Clinical experts' do not come into it, only evidence. I am not sure what 'best practice' means other than practice...
This does not look like an article to be pleased about. it seems to be a mish-mash of second hand material put together by someone with no idea...
I don't disagree with the need for more accountability in medicine. But I think it really is very difficult to see how you rate individual clinics...
On the contrary. Proper trials check that methods work. You then apply them and you can check that you are applying them consistently. But you...
I doubt this can ever be done. For most specialities it is never done because it is realised that there are too many confounders to generate data...
This sounds like a quicker test rather than a better one. I cannot see that antibody based tests can do anything more than indicate that the...
I think the idea is to stick to what can reasonably be called facts. Promising results are something quite different.
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