I had never heard of this MID before getting into ME studies - and I had spent years working on trials and acting as expert witness in the law...
I think it may be the way around. All advocacy groups are pretty much agreed that treatments like CBT and GET are not based on good evidence. The...
No need. That was the sort thing I was referring to - empty vessels.
They are by the empty academic vessels who make most noise, just as coronary artery disease has been. To someone trained in inflammatory pathology...
If I knew the answer @Bill, we wouldn’t be in this mess!
Not in any very meaningful sense of inflammation. There may be some microglial activation but I rather suspect that microglial activation in brain...
Yes, but this is not realistic. Lots of cells use anaerobic respiration - like cartilage cells for instance. Normal brain is aerobic but if there...
My spellchecker screwed up on csf pressure.
Lactate is not a sign of inflammation. It is a sign of altered respiration. I think Younger has conceded that calling this inflammation may not be...
I think it is a fair point that there is a problem with EBM in capitals, not with evidence based medicine. There is certainly a problem that...
Hilda Bastian’s blog makes a lot of important points but, in her own words, it does not go nearly far enough. Presumably there is some value in...
I am fairly that brain tissue itself does not generate pain as a result of injury or inflammation to brain itself. Pain is usually ascribed to...
Probably is certainly way less than would normally be considered adequate evidence for efficacy of a treatment. I think we would in medicine...
I think to be scientific a word just needs to have an adequately defined meaning. Probably has a very precise meaning in ordinary English: a more...
I get that probably is what moderate quality is supposed to mean but you cannot use the same probabilistic statement twice in a sentence. It is a...
I do not see how an editor could have approved ‘moderate certainty evidence that probably...’ This is meaningless. Moderate certainty cannot then...
I am supposed to be properly educated about this, as a professor of medicine and immunology who worked on the role of mutation in immune disease....
‘Evidence-based medicine’ has got a bad name for being recipe-based and that is a potential problem but the ideal is simple and sound. What I...
I think this is well worded. There are potential confusions around ‘evidence-based’ and ‘science - based’ but I think the intention is clear...
It has to be a filter because there is no mechanism for shining a searchlight on your own neural activations, or looking to see what shows up...
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