In biological terms, what happens is that (after the point of no return) IDO1 is now inhibited by its own substrate, Trp. Importantly this can...
Alex, I agree with you that bistability is a natural way to think about CFS. And having grown up in non-linear systems theory in the 1960s before...
I've thought a good deal about this. Ron has too. One way is to simply consume too much Trp. The gut, the BBB and the neurons all use the same...
@Simon M Thanks for thinking about the metabolic trap so carefully. JaimeS sent me your questions, and as I read through them and some of the...
This is a nice summary. The only error is mine, not Simon's. My error was that I said there were, on average, 1.7 damaged copies out of 2. What...
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