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  1. ME/CFS
    Post

    Treating patients suffering from myalgic encephalopathy/chronic fatigue syndrome (ME/CFS) with sodium dichloroacetate, Comhaire 2018

    The trial will be initiated as soon as, and provided that the DCA is officially accepted and registered as a food supplement.
    Post by: ME/CFS, May 30, 2018 in forum: ME/CFS research
  2. ME/CFS
    Post

    Treating patients suffering from myalgic encephalopathy/chronic fatigue syndrome (ME/CFS) with sodium dichloroacetate, Comhaire 2018

    It is strange indeed. The formula generated by the logistic regression analysis with stepwise elimination also includes the total score of the...
    Post by: ME/CFS, May 30, 2018 in forum: ME/CFS research
  3. ME/CFS
    Post

    Treating patients suffering from myalgic encephalopathy/chronic fatigue syndrome (ME/CFS) with sodium dichloroacetate, Comhaire 2018

    Post by: ME/CFS, May 30, 2018 in forum: ME/CFS research
  4. ME/CFS
    Post

    Treating patients suffering from myalgic encephalopathy/chronic fatigue syndrome (ME/CFS) with sodium dichloroacetate, Comhaire 2018

    Post by: ME/CFS, May 30, 2018 in forum: ME/CFS research
  5. ME/CFS
    Post

    Treating patients suffering from myalgic encephalopathy/chronic fatigue syndrome (ME/CFS) with sodium dichloroacetate, Comhaire 2018

    THis comment is perfectly correct. The vertical axis shows (p) not logit (p). Thank you!
    Post by: ME/CFS, May 30, 2018 in forum: ME/CFS research
  6. ME/CFS
    Post

    Treating patients suffering from myalgic encephalopathy/chronic fatigue syndrome (ME/CFS) with sodium dichloroacetate, Comhaire 2018

    What I found is that the calculated formula alows for rather clear differentiation between reponders and non-responders. The (p) in the "logit(p)"...
    Post by: ME/CFS, May 30, 2018 in forum: ME/CFS research
  7. ME/CFS
    Post

    Treating patients suffering from myalgic encephalopathy/chronic fatigue syndrome (ME/CFS) with sodium dichloroacetate, Comhaire 2018

    Post by: ME/CFS, May 30, 2018 in forum: ME/CFS research
  8. ME/CFS
    Post

    Treating patients suffering from myalgic encephalopathy/chronic fatigue syndrome (ME/CFS) with sodium dichloroacetate, Comhaire 2018

    This is a proof of principle, pilot, pragmatic trial. It is what it is, not more or less.
    Post by: ME/CFS, May 30, 2018 in forum: ME/CFS research
  9. ME/CFS
    Post

    Treating patients suffering from myalgic encephalopathy/chronic fatigue syndrome (ME/CFS) with sodium dichloroacetate, Comhaire 2018

    Your comment is correct. However, it is remarkable that there is apparently such formula that is confirmed each time when new patients are...
    Post by: ME/CFS, May 30, 2018 in forum: ME/CFS research
  10. ME/CFS
    Post

    Treating patients suffering from myalgic encephalopathy/chronic fatigue syndrome (ME/CFS) with sodium dichloroacetate, Comhaire 2018

    Post by: ME/CFS, May 30, 2018 in forum: ME/CFS research
  11. ME/CFS
    Post

    Treating patients suffering from myalgic encephalopathy/chronic fatigue syndrome (ME/CFS) with sodium dichloroacetate, Comhaire 2018

    Thank you for your comments and suggestions. I am - indeed - a medical doctor, retired professor of internal medicine, endocrinology (diseases of...
    Post by: ME/CFS, May 30, 2018 in forum: ME/CFS research
  12. ME/CFS
    Post

    Treating patients suffering from myalgic encephalopathy/chronic fatigue syndrome (ME/CFS) with sodium dichloroacetate, Comhaire 2018

    As the number of patients who are included into the pragmatic trial increases, it becomes evident that it is possible to predict with reasonable...
    Post by: ME/CFS, May 29, 2018 in forum: ME/CFS research
  13. ME/CFS
    Post

    A Novel Nutriceutical Treatment of ME/CFS, 2017, Comhaire

    Reply this is indeed based on a relatively small number of observations, and is performed a posteriori, by calculating the formula derived from...
    Post by: ME/CFS, Jan 16, 2018 in forum: ME/CFS research
  14. ME/CFS
    Post

    A Novel Nutriceutical Treatment of ME/CFS, 2017, Comhaire

    As argued before, this is an open-label, proof of principle or proof of concept pilot trial performed in real life circumstances and, therefore,...
    Post by: ME/CFS, Jan 15, 2018 in forum: ME/CFS research
  15. ME/CFS
    Post

    A Novel Nutriceutical Treatment of ME/CFS, 2017, Comhaire

    A pilot, open label, proof-of-principle, pragmatic trial is the first step in a sequence of validation. For the patients who benefit from the...
    Post by: ME/CFS, Jan 14, 2018 in forum: ME/CFS research
  16. ME/CFS
    Post

    A Novel Nutriceutical Treatment of ME/CFS, 2017, Comhaire

    The dose level is between 5 and 10 mg per kg body weight, generally 400 mg once per day.
    Post by: ME/CFS, Jan 13, 2018 in forum: ME/CFS research
  17. ME/CFS
    Post

    A Novel Nutriceutical Treatment of ME/CFS, 2017, Comhaire

    A pragmatic trial is, by definition, not blinded, since it is an open-label, prospective, real life trial. Please look up the definition of...
    Post by: ME/CFS, Jan 13, 2018 in forum: ME/CFS research
  18. ME/CFS
    Post

    A Novel Nutriceutical Treatment of ME/CFS, 2017, Comhaire

    The formulation is fully protected during 12 months while the "novelty" is being checked. During that period "provisional protection" completely...
    Post by: ME/CFS, Jan 12, 2018 in forum: ME/CFS research
  19. ME/CFS
    Post

    A Novel Nutriceutical Treatment of ME/CFS, 2017, Comhaire

    sorry... should read stepwise elimination. ;)
    Post by: ME/CFS, Jan 12, 2018 in forum: ME/CFS research
  20. ME/CFS
    Post

    A Novel Nutriceutical Treatment of ME/CFS, 2017, Comhaire

    in a short "proof of principle" pragmatic trial, reported previously, I have referred to a new nutriceututical treatment for ME/CFS. In a larger...
    Post by: ME/CFS, Jan 12, 2018 in forum: ME/CFS research
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