Are astrocytes suppressed by corticosteroids as well? Also, how effective would corticosteroids if the inflammation is getting worse at the same...
Could PEM be, when neuron action potential fires, use of atp, atp require mitochondria and defective mitochondria generates more ROS, and then ROS...
Yes but, you can ask to try it, in a similar way that ampligen is available I think. It's a matter of convincing a doctor and then convincing...
Wait sorry if this is wrong place for me to ask, but who the heck should I target to see if I were to try to obtain tak 242? I'm a fibro patient...
I had a thought, are we going to attribute pain in cfs due to fibromyalgia or pain in cfs due to cfs? And, if we attribute to fibromyalgia does...
Do most CFS with pain find it beneficial in the same way fibromyalgia patients do? Ie at least does it help as a pain killer?
About narcan vs naltrexone I had the same thought, wondering what the difference was. There are 3 opioid receptors, mu kappa beta or something...
Naltrexone IC50 for LPS NO at 2microM Naltrexone IC50 for LPS NO at 100microM Why the huge discrpency? They used different cell lines?...
Just had another thought, although naltrexone has tlr 7,8,9 antagonism, these are located within the cell, and therefore ligand must be able to...
Ah damn I've misunderstood LDN for a long time, I saw that it inhibited tlr4, so I thought it was a competitive antagonist. No it's non...
I'm starting to doubt the TLR4 hypothesis Dr Younger has, since LDN is only a LPS tlr4 antagonist at the md2 site, there are other ways to bind...
Does anybody understand how Naltrexone inhibits TLR4? If I get this right, naltrexone competitively binds for md2, a protein needed by lps to...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4634939/ 75x more powerful than dextro naltrexone tlr4 antagonist, based on naltrexone Why would...
When they LDN has properties different to Naltrexone, due to dosage, do they mean chemical/biological properties or do they mean different drug...
We need a foundation like this....
Merged thread Naltrexone TLR9 Antagonist? https://www.frontiersin.org/articles/10.3389/fimmu.2017.00809/full This paper says naltrexone has...
Hmmm on this note, researchers were trialling tlr4 antagonists for sepsis. They failed though bc there were other pathways
Merged thread TBI Jeff Wood wrote something on health rising about maybe CFS being a mini tbi with exertion. Is this possible at a cellular...
https://www.takeda.com/what-we-do/access-to-medicines/pre-approval-access Either can get through this, or buy from dodgy research only supplier....
Merged thread TAK242, resatorvid, a tlr4 antagonist Is a non competitive tlr4 antagonist. LDN slows my pem down by a factor of 10, if its...
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