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I've been interested in ciguatera for a while, because exposure to the ciguatoxin can cause long term symptoms that have a lot of similarities with those of ME/CFS. And also because early on in my illness I saw a paper by a Japanese researcher that found similarities in protein expression, I...

I wonder if you could take photos when it is good and bad, not many days apart, perhaps with a tape measure? They might help when you are trying to convince doctors. I get some swelling that comes and goes - I don't wear my watch or rings now - although not as pronounced as what yours sounds...

This study, related to cortisol, has been moved to its own thread: Epigenetic Modifications and Glucocorticoid Sensitivity in ME/CFS, 2017, de Vega, Vernon et al

With the finding of 12,608 differentially methylated sites between ME/CFS patients and healthy controls, this team might be churning out papers for a while, if this paper is any guide. They suggest 13 of the 12,608 are associated with glucocorticoid sensitivity, implicating processes in...

(the rest of the abstract) Methods: We examined the DNA methylome in peripheral blood mononuclear cells (PBMCs) of a larger cohort of female ME/CFS patients using the Illumina HumanMethylation450 BeadChip Array. In parallel to the DNA methylome analysis, we investigated in vitro glucocorticoid...

One issue is that some protein biomarkers might only be different when the body is stressed. For example, one team reported finding that, in healthy people, plasma Cys34 changed to its oxidised form when muscles were worked, but it didn't in people with ME/CFS. Surely there will be proteins...

I haven't read the paper yet but it looks like this group are well aware that the small sample in this study means that this is just a start. I hope they get more funding for this. With the potential for possibly two or more illnesses being included under the ME/CFS label, it would be...

I'm glad you're on the job @Simone. It's dreadfully frustrating. As you and Sean say, Norman Swan comes across as a very credible source of information and he has influence. I wonder why he has the blind spot, if he is friends with Lloyd or Hickie, or had a bad encounter with an ME/CFS...

I think personal stories do have a place in professional journals. For example, there was the recently posted article by a GP who had 6 years seeking, and eventually getting, a diagnosis for a medical condition. She talked about what it was like to be labelled with a functional disorder, and...

The abstract is quite vague. It starts by dividing persistent physical symptoms into those that are medically unexplained and those that are not: It does not, however, create a separate term for persistent physical symptoms that are medically unexplained. So, the rest of the abstract could...

Maybe someone could ask Vicky Whittemore at the NIH?

Does anyone know anything about the consultation? @Simon M

Initially Grenada controlled cases with a lockdown. After an exponential increase in cases in the first half of December 2020, the country applied a partial lockdown to bring it under control again. Arrivals from the UK are currently banned. I'm not saying that Garner caused the Grenada...

What sort of things do the charity standards require, jonathan_h?

We have merged a separate thread also covering Paul Garner's latest blog, including Marky's video, now here: https://www.s4me.info/threads/paul-garner-on-long-covid-and-me-cfs-bmj-articles.15629/page-6#post-319854

Yes, it is. In an early blog, he talked about getting dengue and post-viral fatigue. https://blogs.bmj.com/bmj/2020/05/19/paul-garner-covid-19-and-fatigue-a-game-of-snakes-and-ladders/ And he seems to have gone on holiday during 2020 and got it again. Here's my contribution to the BMJ...

Some posts about Paul Garner have been moved to this thread: Paul Garner on Long Covid and ME/CFS. BMJ articles.

Methotrexate treatment for post-Chik arthritis is ridiculously common for something that is not appropriate for the damage mechanism. Still, I guess we have seen widespread use of a treatment is not proof of efficacy. There are some trials where methotrexate seemed promising but the...

An old quote of Esther12's. It seems that with ME/CFS, it's hard to be too cynical. It occurs to me that, if you were in charge of protecting the BPS edifice, 'turning' Paul Garner, with his potential influence on Cochrane reports, would bring about a lot of benefit for a relatively small...

(This is me speaking personally, not as a moderator.) While I appreciate temperate responses are almost always the best strategy, I think we have to acknowledge the great harm Paul Garner has done with his recent statements. He has been educated in science, and holds positions where he has the...