I'm beginning to think that GWAS isn't so great when there are multiple damaging mutations that are very common in the population in one...
Does anyone know if this is what Ian Lipkin presented at the NIH ME/CFS conference in April? If I remember right he was intending to do a similar...
It seems Norman Booth, had similar concerns about the state of the Neutrophils which he discussed with John Mclaren Howard the one who came up...
With $5MM per year in funding, one would think that would allow a full time person to be 100% dedicated to ME/CFS. Or is that $5MM being used to...
I agree with everything you say Tom about the importance of pilot studies. To be clear, a successful pilot study does not mean more NIH funding...
Unfortunately the paper written by the Klimas team using this approach is anything but robust. 23andMe is low quality and the data is full of...
@Chris Ponting Would it be possible for you to enquire whether the 100,000 Genomes project has ME/CFS data available? According to this article...
NIH-funded HRV Study announced for ME/CFS at Stony Brook University [MEDIA]
I thought this was interesting. This is similar to what Nancy Klimas is reporting in her videos about the differences between GWI and ME/CFS
Just to clarify the question. Naviaux second study after the first was published was 3 years ago. The second study has not yet been published...
Done. [MEDIA]
For the fun of it I took a look at the high p value phenotypes for IDO1 and IDO2. Not sure it means much for the metabolic trap theory, but it was...
If anyone is interested you can search by variant with the "Phewas" search option and you will get a table you can sort by p-value for that...
Thanks @Andy The best bit for me was that the interview took place in Rockville MD. I played pool a few times ~20 years ago at Dave and Busters...
@RDP @Chris Ponting . I get lost following the explanation but this is what I found. Let me know if this makes sense? Here is the coding MVV file...
Can anyone answer @Lucibee question? [Note Supplementary table 1 mentioned in Simons blog now lists 2017 people, also confirmed on biobank study...
I've had trouble too understanding the columns. You are correct with the meaning. here is one explanation Source :...
I've come back to this thread after Chris Ponting has posted on the metabolic trap thread a link to anlayse the ME/CFS patient data on the UK...
For anyone interested here are the 5 variants @RDP has discussed R248W = rs10109853 Y359STOP = rs4503083 S252T = rs35212142 I127V = rs4736794...
As @sb4 states it could depend on the number of cells of a specific type that are in the trap. Take dendritic cells for example, the ones they are...
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