Congratulations @mariovitali It might be worth trying to get in touch with OMF again regarding their Analyzing Patient Data study now that you...
@Simone I know this is not about a mouse model of ME/CFS but here is an excerpt from the 2018 Stanford Symposium about possibly modelling the IDO...
Did someone say Mouse? Did you call me? Please don't experiment on me!!!!!! @Simone the closest I can think of is Gulf War Illness which presents...
Discussion section excerpts. Why is repeatability in ME so hard!
It seems melatonin is an indoleamine according to this https://en.wikipedia.org/wiki/Indolamines It seems the hypothalmus controls melatonin...
@mariovitali have you any idea why Melatonin is up near the top in your recent analysis? I haven't seen much data about Melatonin levels and ME....
I guess it could - the more you have on the same gene the more likely that there will be an effect - warfarin dosage if used may need to be...
@mariovitali Disclaimer : I'm not much of an expert. Just teaching myself as I go along (thank you Klimas paper and open data) According to...
According to gnomAd the rsID you mention rs1801175 is predicted to be deleterious https://gnomad.broadinstitute.org/variant/17-41055964-C-T...
Did you see this twitter thread @Grigor . [MEDIA] Someone combined the tweets in a thread reader app. Good overall summary....
I was expecting more discussion here on this paper than has happened - very very very poor analysis of data in this paper by the researchers. *...
What is your interest in SERPINE1 @mariovitali ? According to this mutations can cause mild to moderate bleeding........
Oooooooooooo. Does this mean he is on a hunt for the mysterious "something in the blood"? He must be convinced about it if he is giving a talk on...
It's acutally very similar. A % sign was added after MAF=0.06 instead of quoting as MAF=0.06 = 6% From dbSNP (expand the + sign to see 1000...
@mariovitali I think your MAF=0.06% is wrong. Databases are showing 8% allele frequency https://www.ncbi.nlm.nih.gov/snp/rs28371725 OpenSNP is...
The reference frequency data used in the paper seems to be based on Kaviar frequency from what I can see which in many cases is way different from...
I spent some time looking at Supplemental table 2 vs the data in my 23andMe v5 file. I checked CADD scores > 1 in supplementary table 2 and found...
Tagging @mariovitali as you might want to look at supplemental table 2 and re-sort by CADD score to see if any of your liver genes spring out to...
The one thing I'm not sure about is 23andMe coverage accuracy which could render this paper questionable. e.g. The first and only data point I...
Fereshteh Jahanbani from the Stanford Genome Technology Center wrote a piece for OMF's #MayMomentum Story: The Journey of an ME/CFS Researcher...
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