I can't see anything about blinding/placebo on the poster Rapamycin is a bit of a nasty drug so I would be cautious until we have clear evidence...
Could be commercially sensitive
a useful tool if looking at specific enzymes is protein atlas. If you have specific lipids in mind and can trace back to a protein of interest,...
if we read this in good faith there might be nuance lost in translation. it's possible to me this paper is telling us about the specific role of...
general comment some things, particularly lipid metabolic pathways, are very variable between tissues (whether relevant enzymes are even...
They have transfected mice with (human?) PKM2, plus overexpressor and knockout groups, and then made them to do exercise. How is that ME? ?
thanks, I didn't know PR pre-dated s4me. I had actually forgotten about it since I haven't really looked there very much
Two leading experts sounds good to me. I look forward to whenever your ideas are out there so that they can inform my own research ideas in a...
Ah there mustn't have been a thread for this afterall. The paper stood out to me yesterday and I couldn't find a thread for it (when I made the...
Are we aware of any consensus in these areas in ME/CFS (no matter how small?) What do we think about the TGF-β angle in 2025
Generally yes but lit reviews are a little different as they are often an entry point for new readers. Since they are discussing other illnesses...
These bits led me to believe (I think fairly) that you were referring to ROS in disease in general, as well as human disease research in general....
I initially began my reply by responding point by point but it became pretty clear that there’s a central issue here that it would be more...
"Oxidative stress" would generally be referring to a biological scenario that involves increased likelihood of damage to molecules usually by...
the abstract explains what they are meaning "Using a combination of flow cytometry, bulk RNA-seq analysis, mass spectrometry, and systems...
Can study them inside live samples from patients - easier or harder depending on the tissue of interest. We have done it in circulating immune...
"mtDNA analysis from muscle at 46 years of age revealed the m.8753_16,566 deletion with <10 % heteroplasmy. The deletion was larger than in...
mTORC1 activation as a primary upstream factor driving the disease (across which compartments - the whole body?) doesn't seem to fit with a lot of...
we have a PhD student who is characterising cell lines from people with mutations to genes encoding complex V subunits, and who is also...
Yeah this was the really big one from Prof Gras' lab on the topic
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