This raises a few questions to me. 1) What is the stimulus? 2) Is the response to stimulus abnormal? (& how) 3) Which pwME does this apply to or...
I reckon we are lucky if it's only two.
I think we need a study of this against a control group that is also exposed to potentially myriad medications or other relevant factors. This...
Regarding the new (2024) paper: I'm confused. I don't understand how the causal direction was determined. Red to highlight the conclusions...
I consider this mandatory, remarkable reading. I am not sure what OP's background is, so forgive me if this is misplaced, but @ME/CFS Skeptic if...
And this is why it is important that it gets very clearly stated in publication. When applying for govt grants that are administered with a...
Amber seems to have written this in a very humble and careful way (which I wish was more common) so it may just reflect the complexity of what she...
That is unfortunate. I find that the accumulating mishmash of nonstandard definitions muddies the waters and damages our credibility as a field.
Is this a newly accepted umbrella term for ME/CFS / LC / etc, or something else or older, or just another new acronym for the pile? I try to keep...
This is unusual, but it would be good to ask them to describe the rationale underlying the chosen approach
I am expecting in August at this stage, finishing up a grant with a tight deadline and waiting for a few logistical processes to settle.
??
This sounds like a lot of parameters for one blood test. Is there a diagnostic test in clinical use that uses (if they get to this point) "a test...
"A recent study of post-infectious ME/CFS (N = 17) and healthy controls (N = 21) assessed a comprehensive panel of physiological, physical,...
seahorse data while reporting negative values :emoji_skull: You can't have negative spare capacity If the basal is higher than the spare...
I did a kind of experiment on myself while I had about 5 weeks of post-COVID symptoms (mostly cognitive issues + light sensitivity + fatigue,...
The problem with consensus is that there will always be subjectivity and bias involved in determining it. Assessments of "relevance" are going to...
In strongly agreeing with this I would also add as a general comment to readers that I think tissue context always needs to be front and centre...
If I am reading this right their ME/CFS data is the RNAseq data from the Wallitt study muscle samples. DNA -> RNA -> protein -> metabolic...
My guess is regulatory disarray. Something in metabolism / signalling going wrong that has wide ranging knock-on effects that include changes to...
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