Perhaps the authors felt that the outcomes of thousands of concurrent measurements could not be fairly represented or even-handedly conveyed by...
The kinetics of transient activation by immunological stimulus are different between individuals. And yes this extends to cells in vitro, we have...
Cerebral hypoperfusion causes vascular dementia. Do we know if VaD and ME/CFS are frequently present together? I haven't encountered it, but the...
This is pretty technical. We're on the same page. :) This is a very good example of why you can't have too much detail in a methods section. For...
It looks like they've applied whole exosomes, not just DNA to the cells, so this part should be unaffected by that issue. (The raw result anyway),...
Did they? Without a standard curve in the qPCR or without a total DNA quantification assay, I can't see how they'd know this. The qPCR, as shown,...
I don't see how this is publishable unless I have missed something. I do not see mention of a DNA loading control/housekeeping gene or any...
First, awesome paper and glad to see the Morten lab getting their ME/CFS work into the literature. Very nice to see other people looking to...
Did anybody catch if the exercise event durations for each individual or clinical group were included in the paper? Can't see it at the moment....
Unless there is a specific reason for this concern, it could be applied to any scientific observation. Of course, as a reader this is always borne...
This is cool, in line with what prior work has been suggesting and from a new angle (new cell types, more direct measures of function). I love...
Assumption here being that CSF carries the underlying signature of both diseases.
Hey Simon, really good point. Sorry for the extreme delay in seeing this. Yep, true. I am increasingly thinking that the way to approach these...
Hey everybody. Sorry for the absence, have been overwhelmed with work. This discussion is important and don't worry about scaring me away or...
Thank you, Hutan. I am glad to take part in whichever way is appropriate and productive. The driver for why we work in this field should always be...
Thanks Snowy. I can always count on you for this kind of useful scrutiny. And yes, you are right - there is no intrinsic reason for a link....
Re the discussion of glutamine metabolism, glucose, fats (etc) in prior work: indeed, nothing is proven yet. Good news is that people are doing...
A couple of things. 1) (related) Since I could not see author contributions listed in this paper and I am in the author list, FYI I was asked to...
Hello people, a few answers, comments and a general statement I've wanted to make which is probably best placed in this thread. Hi there, thanks...
Sure, just didn't want the text itself of Sarah's mobile number being immortalised in google.
Separate names with a comma.
