How expensive (for a large-very large WGS)? Is anyone currently trying to get funding for it and could it happen in parallel to the GWAS? Thank you.
That's a very interesting idea. I am not sure though, that ME/CFS cells (we haven't looked at too many celltypes?) behave normally or work as in...
This is more or less the model that many of the "ME/CFS = EV infection" proponents use. I think it's somewhat plausible. What is important to add...
Very interesting study, I thought I would mention that measures to increase volume (saline, desmo,fludro,..) worked well for me in the earlier...
I have measured all of them and GFAP in my own samples (very severe ME), all negative, but again, I did not expect them to be elevated, as I think...
Thank you, I have read this study! I think it's highly underrated how significant these findings could be, we need much larger samples though. If...
I find it likely that it is a property of LC and also ME/CFS, but very unlikely that GFAP remains elevated for such a long period without...
The main issue at hand, in terms of commonly used biomarkers to determine CNS damage (such as GFAP), is that LC patients were not controlled for...
What's pretty insane about this, apart from the study population size, is that GDF15 is fully expected to be higher in an older population.
I doubt that GDF15 will be a good predictor/biomarker for LC and ME/CFS, but the study design (not in terms of how many patients were used!) is...
Could someone with more spoons summarise Dr. Edwards' and Dr. Armstrong's points in a few paragraphs? I will then use this this info and run it...
I would love to hear a fair critique of the methodology used in this paper by you, with this valuable information the methodology might actually...
I am 100% certain that I lose water during PEM. I am bedridden, my caregivers measure every single ml of input and output. They have been doing...
They all had an insufficient workup during the acute and sub-acute stage of their disease/trigger event, making it close to impossible to hunt...
Thank you again, Chris. Your hypothesis seems to indicate that mitochondria are not functioning correctly, the obvious go to organelle, do you...
Thank you! When you say full system level, what do you mean by that? Every cell is affected? Can you give us a little preview of what data will...
That's basially what is causing ME/CFS, but somehow everybody still talks about 'no neurological' damage all the time.
There should be, very roughly of course, thousands of families worldwide with more than $50 MIO at their hands who have a close family member with...
U Understood, thank you. If you see a realistic chance to include a small PEM pilot cohort, and if it’s just 5-10 samples, and if you think...
Thank you for your insights, @chillier ! Have you considered using PEM samples for your projects and to compare them? I can not really say a lot...
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