Also implicated in mucking around with mitochondria :p http://www.mitoaction.org/files/Mito Toxins_0.pdf
Beta blockers are indicated as causing problems with mitochondrial function, and one of the milder listed lactic acidosis symptoms I had with...
I think they vaguely reported that outcomes were the same for the subgroups meeting the different criteria. Not sure I believe them though, and...
PACE authors claimed that about half of their Oxford patients also met London criteria, which includes a vague form of exercise intolerance: I...
"The study participants didn't like the scientific method, so I stopped using it. Instead, they wanted to tell me what they felt the results...
@Jonathan Edwards - Here's my notes regarding the GET evidence: Fulcher 1997 (1++) - 66 patients, Oxford, 2.7 years ill, 12 weeks GET v...
https://www.nice.org.uk/guidance/cg53/evidence/full-guideline-appendix-1-196524110 contains the evaluations of the evidence, and a summary of...
I don't remember where it is, but I think it was something Wessely said off the cuff regarding the lowered thresholds required for recovery in PACE.
I don't think they clarified, but it could happen if another symptom was more prominent than fatigue. I doubt they would usually exclude patients...
I don't much care for the term "lady" either. Too often it's used to separate women into groups of those who should be treated respectfully and...
I think we have a strong argument along these lines regarding most exercise recommendations: "exercise is beneficial in healthy people, ergo it...
Profound fatigue is not the same as requiring that fatigue be the principal symptom. "Profound" and "principal" mean very different things.
In the US, most healthy people have yearly physicals to screen for some nasty problems which can show up early on basic (cheap) blood tests. It...
The problem is that dealing with NICE guidance is not about PACE. It's about a bunch of studies, some of which show objective improvements. The...
There was at least one GET trial which showed CPET improvements. Of course, the patients selected for that study had normal CPET scores even...
Agreed. Chronic fatigue is a symptom in many diseases, and is probably better described as a general symptom of illness rather than indicative of...
CCC and Fukuda require fatigue, but not as the explicit principal symptom. ICC requires fatigability but not fatigue. SEID requires fatigue, but...
Oxford requires fatigue to be the principal symptom, which is not the experience of many ME patients. Oxford also requires the presence of mental...
This is what the NHS website says about what they expect from a lay person (live version doesn't work, so this is the cache): I'm getting the...
Unsurprisingly, given her position, Pugh seems rather focused on ME in the context of mental health: This is actually a really good suggestion:
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