I still haven't heard any satisfactory explanation of PEM with itaconate shunt or whatever-trap. So, I dug up and re-read Cort's writing on it,...
Younger talks about morphing microglia from inflammatory state to anti-inflammatory one. But he doesn't say how HIFU does that. It seems to me...
If IH or CCI can mimic ME/CFS, I suppose there are other conditions that can also mimic ME/CFS. The fatigue and PEM in those conditions wouldn't...
Maybe I'm suffering a jet lag after travelling 16 time zones, but I'm having a hard time understanding what this thread is trying to accomplish....
Anybody with an idea how this itaconate function/malfunction may explain PEM?
They assign the same score for 45min of medium activities and 30min of strenuous one. I think you will find yourself crashing real badly if you do...
Is the off-level use of safe drugs really comparable to assisted suicide? Or is it just your belief? If it is your belief, is it fair to impose...
Caffeine didn't make any difference when I was sicker. Ephedrine had some effect though. But caffeine also started to have some effect,...
Or PEM afterwards. It's rather meaningless to boost the distance if the increased distance triggered PEM.
I don't quite understand. If you have an intractable disease, you can either wait for the science to find the solution or do something on your...
The heterogenous nature is why I suspect some drugs may work for some people even if it doesn't for the majority. Most drugs probably won't do...
I'll have to summon my analogy of getting lost in the wilderness again. If you believe the rescue chopper is coming soon enough, the best thing to...
This sure sounds like CBT/GET people: average patients don't have knowledge, so we the experts should shove it down their throat. It is as...
That depends on your belief of the odds of your ME/CFS getting worse by X vs odds of the science coming through for you. As much as some people...
Yep, there is that conditioning effect. The problem, of course, is that it doesn't improve PEM threshold. For most of us anyway. You keep pushing...
PACE also reported improvement with 6MWT after 6mo. Apart from various issues that experts raised with the data, 6 mo was just not long enough...
No it doesn't. I meant abstract concept for me, to be concretized by practitioners like you.
All that says is that the therapy doesn't work for enough people and those that improved *could* be by chance alone. It doesn't necessarily mean...
Exactly. To borrow @Creekside, it doesn't have to be one or the other. I'm normally a hardcore proponent of forming hypothesis and then testing,...
That is what I meant by frequentist science. The objective truth is black and white and p < 0.05 means black. (well, actually I don't know much...
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