Somewhere in there, it talks about microglial cells producing CCL2 which causes monocytes to infiltrate the BBB. Would that count as the breach?...
That may well be. The problem is with the ambiguity of "exercise intolerance". People with cardiopulmonary/metabolic problems, often described as...
That will lead to a problem of distinguishing PEM from the exercise intolerance from the likes of COPD. Some of the "rapid effects" are clearly...
Fatigue in chronic liver disease: New insights and therapeutic approaches - Swain - 2019 - Liver International - Wiley Online Library Liver...
Not sure what exactly is meant by "exercise intolerance" here. But people often use "exercise intolerance" to mean inability to exercise. That is...
TLL could be yet another trigger for MECFS. There was a paper how the liver inflammation leads to BBB breach and monocyte infiltration through...
Has there been an RCT for MECFS? I don't seem to be able to find one. There are several papers on dopamine's ability to modulate glial cells,...
Stress, perceived or otherwise, could lead to physiological changes. Not knowing yet doesn't mean that the underlying changes don't exist. In...
Thanks for the info. I didn't know that metformin reduced the viral load.
The problem with PASC is that it is a collection of all symptoms ranging from anosmia to kidney/lung damage to diabetes, etc, etc, with MECFS...
BTW, the pace can be measured with an activity tracker. I just found that it was more accurate to measure them manually. My max pace for 7/3/2016,...
I didn't feel anything after the first two, but the last one put me in the penalty box for 2 weeks. I couldn't figure out why till I remembered...
That's a great question! :) I don't think anybody really knows what fatigue is, other than how it makes you feel. At the end of it, I think you...
Measuring fatigue/PEM is something I've been looking into for a while. I found that the amount of time lying down or walking speed is a reasonable...
If it is the same study by Nakatomi/Watanabe that I'm thinking (one that came out of Japan about 10 years ago?), it failed to get replicated. I...
You are not gonna get an argument from me on that either. Overtraining syndrome, post-viral syndrome => MECFS. Same MECFS regardless of the...
No, that's not what I'm saying. Saying MECFS is post-viral means viral infection is required for MECFS. I'm saying MECFS is just what MECFS...
Well, ok, that was my words for "Long OTS" that lasts more than 6 months. Those are indeed diagnosed as MECFS because, well, they meet the MECFS...
Nobody has problem saying their MECFS is post-viral. But there are some people who are quick to dismiss non-viral onset. There were people...
Nobody said ME isn't post-viral. Viral onset may be the most common onset, but it is not the only one. There are several onset triggers and too...
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