Not sure if the analogy stands. Monje study was specifically about brain fog of long-COVID, not long-COVID or MECFS in general. She gave...
Nobody should! I'm not a biomedical scientist. Could well be a case of seeing what I want to see, but most of the reports of microglial...
What purpose of reclassifying PEM would serve? Unless you think that different PEMs are different phenomena caused by different factors, it...
Microglial activation has been linked to concussion fatigue, age related fatigue, etc. It has also been implicated to brain fog in chemotherapy,...
One Idea I had was to knock out all glial cells and see the MECFS patient recover. That would conclusively prove if they are directly involved in...
I'll have to disagree. You don't have to know what is under the hood to build a model to study or predict. This is routinely done in systems...
I don't know brain physiology well enough to comment, but here is a Statnews article and the actual paper. She is actually a chemo fog researcher,...
I used to be one (without mentally triggered PEM). Then I recently did a serious mental exertion trying to solve a problem (with a language design...
This is not surprising given the publish-or-perish culture of academia, medical/bio science community in particular. Theo Baker did an expose on...
Yeah, that "initial phase" will have to lead to a common mechanism, something like physical, mental -> inflammation -> PEM, for example. But...
No it doesn't, but we need to. The study presents muscular changes and putatively link it to PEM. It's possible that the observed physiological...
And what does this study say about PEM from mental exertion? The short answer is: it doesn't. Since PEM from mental exertion is the same, and...
Yeah, no idea if microglia is the ground zero or not. But the microglial activation, perhaps as the result of the hypersensitivity somewhere else,...
(This is a long thread and I'm catching up whenever I have time:)) Michelle Monje of Stanford recently showed that the microglial activation in...
That's the thing: we don't know, and we are imagining something that we don't know without any proof. It's like saying there may or may not be...
That sounds about right. The minute inflammation from, say, walking a block, won't be detectable with C-reactive testing. It's been shown that...
I actually think it is the other way around. The idea that MECFS has multiple subtypes have been hindering the progress, imo, as such notion...
Hi all, I guess I'm a bit late to the party. For what it's worth, I think MECFS is a hypersensitivity to low grade inflammation. Typical PEM that...
This is something I found rather interesting as I progressed. When I was in severe/moderate end of the spectrum, the threshold was a bright red...
Howdy Mij, There are some patients reporting PEM immediately after exertion. I usually experience minor fatigue within 30 min, sometimes followed...
Separate names with a comma.
