I’m just happy to take what I can get for now. Being bedridden is hell I desperately needed a break from it.
Currently to me these are the hypotheses for Abilify efficacy in ME: 1. Positively affects neurotransmitter or signaling dysfunction via...
A good summary document on brilaroxazine from an investment research firm looking at Reviva....
https://en.m.wikipedia.org/wiki/Brilaroxazine It’s almost identical molecular structure to aripiprazole, with only a single carbon change in the...
For those of you who also read PR, we’ve also discussed potential alternative DSS drugs and add-ons there as there are many people who responded...
I personally take from the referenced paper that this is some additional evidence documenting Abilify’s potential anti-inflammatory molecular...
Yes, it doesn’t feel stimulating at all. Symptoms have reduced and I just feel better. But I’m not restless, mind not racing, not feeling pushed...
Your time to response (7-10 days) is more typical from what I read. People report that benefits continue to increase for a while after that until...
I totally agree. Given though what I and many others are (or have) experienced with low-dose Abilify really says to me that likely there are...
I’m taking moclobemide (RIMA MAOI) at the lowest therapeutic dose of 300 mg/day. I’d been taking moclobemide for over 2 months by itself before...
You could’ve written this about me too. I had same the experience as you @benji. I’m also trialing Abilify 0.5 mg and have had a really...
I totally agree. But this is another problematic dimension regarding ME RCTs. Though even if you have well-crafted, physical quantitative...
[MEDIA] Spot on
It’s just he stated, and I’m paraphrasing, that LC and CFS are distinct because LC has what can be described as a old/broken battery. That why I...
I know this has been discussed before, but maybe worth bringing up again. Regarding ME treatment RCTs, I generally worry about the chances of...
Has it been shown that steroids are ineffective in ME/CFS in very short-term usage? I understand they aren’t a usable long-term treatment, but I...
I think Syk elevated CRP assumes the inflammation is systemic or at least outside CNS? I believe that Syk and Src are part of a microglial...
The pharma company that discovered aripiprazole already has a new FDA approved drug for the same indications, brexipiprazole (Rexulti). So I have...
To me the paper is interesting not in relation to COVID-19, but to possible (hypothetical) mechanism of action in ME/CFS.
Syk and Src-targeted anti-inflammatory activity of aripiprazole, an atypical antipsychotic. Yoo et al. Biochem Pharmacol (2018)
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