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  1. leokitten
    Post

    Open‐label study with the monoamine stabilizer (‐)‐OSU6162 in myalgic encephalomyelitis/chronic fatigue syndrome, Haghighi et al, 2021

    This paper is definitely better than the Abilify retrospective paper, even though it too has limitations being single-arm open label. OSU6162 and...
    Post by: leokitten, Feb 6, 2021 in forum: ME/CFS research
  2. leokitten
    Post

    A randomised controlled trial of the monoaminergic stabiliser (-)-OSU6162 in treatment of ME/CFS (2017) Nilsson et al.

    Am I completely misreading the study design? To me the major design flaw in this study and possibly a huge reason why they had a null result is...
    Post by: leokitten, Feb 6, 2021 in forum: ME/CFS research
  3. leokitten
    Thread

    Who Are We Without Our Jobs? — The Cut

    https://www.thecut.com/2021/02/who-are-we-without-our-jobs.html
    Thread by: leokitten, Feb 5, 2021, 20 replies, in forum: Work, Finances and Disability Insurance
  4. leokitten
    Post

    Off label use of Aripiprazole shows promise as a treatment for Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS) Crosby et al. 2021

    Trazodone - StatPearls - NCBI Bookshelf
    Post by: leokitten, Feb 5, 2021 in forum: ME/CFS research
  5. leokitten
    Post

    The biology of coronavirus COVID-19 - including research and treatments

    Beneficial effects of colchicine for moderate to severe COVID-19: a randomised, double-blinded, placebo-controlled clinical trial. Lopes et al....
    Post by: leokitten, Feb 5, 2021 in forum: Epidemics (including Covid-19, not Long Covid)
  6. leokitten
    Post

    Off label use of Aripiprazole shows promise as a treatment for Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS) Crosby et al. 2021

    Really so taking an antidepressant would jeopardize your ME disability claim too? Or taking LDN would jeopardize it because it’s a drug used to...
    Post by: leokitten, Feb 4, 2021 in forum: ME/CFS research
  7. leokitten
    Post

    Off label use of Aripiprazole shows promise as a treatment for Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS) Crosby et al. 2021

    Not an agonist but a functionally selective dopamine stabilizer, like Abilify (in addition to the serotinergic mechanisms Abilify has) Dopamine...
    Post by: leokitten, Feb 4, 2021 in forum: ME/CFS research
  8. leokitten
    Post

    Off label use of Aripiprazole shows promise as a treatment for Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS) Crosby et al. 2021

    I think most everyone is adult and able to inform themselves enough to evaluate the pros/cons with their ME doctor and then weigh the personal...
    Post by: leokitten, Feb 4, 2021 in forum: ME/CFS research
  9. leokitten
    Thread

    Why is an ordinary life not good enough anymore? — Alain de Botton

    [MEDIA] Relevant to ME too and how we can perceive ourselves after loss due to this illness and how we can be negatively perceived by others.
    Thread by: leokitten, Feb 4, 2021, 6 replies, in forum: Relationships and coping
  10. leokitten
    Post

    Off label use of Aripiprazole shows promise as a treatment for Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS) Crosby et al. 2021

    Because research is very incremental, single papers aren’t meant to be the end all be all. It was an initial step. Most single research papers...
    Post by: leokitten, Feb 4, 2021 in forum: ME/CFS research
  11. leokitten
    Post

    Off label use of Aripiprazole shows promise as a treatment for Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS) Crosby et al. 2021

    I believe the paper didn’t suggest this, and yes you are right a retro study like this has major flaws/limitations. But it’s a start and I believe...
    Post by: leokitten, Feb 4, 2021 in forum: ME/CFS research
  12. leokitten
    Post

    Off label use of Aripiprazole shows promise as a treatment for Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS) Crosby et al. 2021

    True they should’ve mentioned something, but no there are reports of the drug continuing to work without tolerance in a minority of patients.
    Post by: leokitten, Feb 3, 2021 in forum: ME/CFS research
  13. leokitten
    Post

    Off label use of Aripiprazole shows promise as a treatment for Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS) Crosby et al. 2021

    This has already been litigated ad nauseum in other threads, the list of side effects and negative information people always cite is for much...
    Post by: leokitten, Feb 3, 2021 in forum: ME/CFS research
  14. leokitten
    Thread

    Chronic active Epstein-Barr virus infection involving gastrointestinal tract mimicking inflammatory bowel disease. Xu et al. BMC Gastroenterol (2020)

    https://bmcgastroenterol.biomedcentral.com/articles/10.1186/s12876-020-01395-9 Background Chronic active Epstein-Barr virus infection (CAEBV) is...
    Thread by: leokitten, Feb 2, 2021, 0 replies, in forum: Other health news and research
  15. leokitten
    Post

    Hypothesis: Mechanisms That Prevent Recovery in Prolonged ICU Patients Also Underlie ME/CFS: 2021, Stanculescu, Larsson and Bergquist

    I understand that and indeed it could be true, but the two studies you referenced didn’t account for disease severity as a confounding factor or...
    Post by: leokitten, Jan 31, 2021 in forum: ME/CFS research
  16. leokitten
    Post

    Hypothesis: Mechanisms That Prevent Recovery in Prolonged ICU Patients Also Underlie ME/CFS: 2021, Stanculescu, Larsson and Bergquist

    Both of these small studies were referred to in the hypothesis paper. There were some important flaws in these studies, like not looking at...
    Post by: leokitten, Jan 31, 2021 in forum: ME/CFS research
  17. leokitten
    Post

    Hypothesis: Mechanisms That Prevent Recovery in Prolonged ICU Patients Also Underlie ME/CFS: 2021, Stanculescu, Larsson and Bergquist

    I encourage people to read the entire paper. Endocrine dysfunction hasn’t been studied to death in ME. Nothing has been studied to death in ME...
    Post by: leokitten, Jan 30, 2021 in forum: ME/CFS research
  18. leokitten
    Post

    Hypothesis: Mechanisms That Prevent Recovery in Prolonged ICU Patients Also Underlie ME/CFS: 2021, Stanculescu, Larsson and Bergquist

    I would encourage people to read up on the functions of the hypothalamus and pituitary gland. This system is central to maintaining homeostasis...
    Post by: leokitten, Jan 30, 2021 in forum: ME/CFS research
  19. leokitten
    Post

    Hypothesis: Mechanisms That Prevent Recovery in Prolonged ICU Patients Also Underlie ME/CFS: 2021, Stanculescu, Larsson and Bergquist

    Both Fluge & Mella and Ron Davis do not know if it’s a single factor that’s in the blood causing metabolic dysfunction. I’ve always wondered why...
    Post by: leokitten, Jan 30, 2021 in forum: ME/CFS research
  20. leokitten
    Post

    Hypothesis: Mechanisms That Prevent Recovery in Prolonged ICU Patients Also Underlie ME/CFS: 2021, Stanculescu, Larsson and Bergquist

    I know this is total speculation, but maybe the people with CCI/AAI and ME had pressure on their hypothalamus or pituitary gland due this...
    Post by: leokitten, Jan 29, 2021 in forum: ME/CFS research
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