But do we have any indication that "cognitive fatigue" would arise from a lack of local ATP? Does it not seem more likely that it would be...
I agree with @Murph, as far as informally testing your idea this seems as good as anything you could do on your own. Of course wine also contains...
Yes, I agree that local arguments can still make sense but then I see no reason to keep on talking about global energy consumption as is commonly...
I would guess the problem with MS would be that it is also a neurodegenerative disease so a cross comparison to understand cognitive problems in...
And perhaps equally important doing something less cognitively demanding doesn't require more energy (in the sense of ATP) than doing something...
I seem to remember Ron Davis getting a sizeable grant to do genetic work on ME/CFS? Am I misremembering this or did something get published?
Thanks for the responses! I'll get to the other messages later, but wanted to clarify what I meant in this part of the message. My idea was that...
What do you mean by trivial activity? Aren't all cognitive activities trivial when it comes to ATP consumption?
I don't want to come off to harsh but I am left wandering: What do you think @jnmaciuch is different about this than the other hundreds of stories...
@Dakota15 are you aware of any news surrounding genetic work happening at RECOVER?
Looks like you're right, to my own suprise they have all been small. I can only find one larger one (52 000 cases - self identified and recruited...
There have been several GWAS on LC across the globe, some of which have been discussed on this forum. The problem, as always, has been the...
Perhaps I'm the one causing the confusion, or at least I didn't mean to say that FUNCAP is intended to be a measure of fatigue or PEM. Here is an...
But how do you assess levels of granularity when a priori it isn't designed to measure all aspects of PEM, doesn't capture cumulative efforts and...
But cancer is not a syndrome. If you have inherited cancer syndrome that doesn't mean you have cancer and vice versa. Asymptomatic ME/CFS makes...
What do you mean by more nuanced? By design it doesn't capture all aspects of ME/CFS and it might not be possible to know how much of everything...
But from my understanding a syndrome is nothing but the presence of certain symptoms that are deemed to be indicative of an underlying process....
But ME/CFS as currently defined is the presence of symptoms, so by definition there is no asymptomatic ME/CFS. If you are HIV positive but don't...
I think so too, but of course it only captures certain aspects and other PROMS probably don't exist to capture other aspects that need to be...
In which case it should be a priori clear that no test is needed to prove the realness of symptoms or disability experienced. What is needed is...
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