I’m aware! I don’t think malic acid would “activate” MAS, just potentially compensate for a lack of reducing agents getting into the mitochondrion...
That’s fascinating, considering some other parts of my experience. Malic acid alone gave me great physical energy at the expense of worse brain...
It seems like the only books that matter are the ones from the insurance company
Any chance those results are published or soon-to-be published? I'd be extremely interested to look at them. I'm sure other members on this forum...
No problem! HiF-1 is hypoxia inducible factor (a nobel prize winning discovery where one of the winners has quite the history of fraud, if you're...
It depends on where exactly the malate-aspartate shuttle is being inhibited (if it is at all). If it's being inhibited upstream at succinate...
Explain like I'm brain-foggy: Background: Glycolysis is the first step in cellular metabolism. It can produce some ATP on its own, but most cells...
Some interesting tidbits on temporal dynamics:
Explain like I'm brain-foggy: Malate is a TCA cycle metabolite critical for ATP production through oxidative phosphorylation. Its role in...
The reason I'm interested in this is a possible time course that could potentially line up with PEM, [edit: and the idea that short term...
Two-stage metabolic remodelling in macrophages in response to lipopolysaccharide and interferon-γ stimulation Gretchen L Seim, Emily C Britt,...
Additional background from the introduction:
Malate initiates a proton-sensing pathway essential for pH regulation of inflammation Yu-jia-nan Chen, Rong-chen Shi, Yuan-cai Xiang, Li Fan,...
Interferon Gamma Induces Reversible Metabolic Reprogramming of M1 Macrophages to Sustain Cell Viability and Pro-Inflammatory Activity Feilong...
Hard to give an exact answer since my entire experience of ME changed quite dramatically with the stimulants. Pre-stimulants I was mostly...
Vyvanse and adderall, vyvanse gets converted into adderall (dextroamphetamine) in the body. Both are monoamine reuptake inhibitors acting on...
That's my biggest complaint with the NASEM definition. It basically boils down Long COVID to "anything that could ever happen to you other than...
Okay, having had a chance to revisit the paper: 1) It looks like the actual clustering (Fig 7A) was in fact done on flow cytometry markers and not...
"Our study found that staring at a wall was a cost-effective solution for type I diabetes, because staring at a wall is cheaper than insulin."
[IMG] Fig 3: Similarly no change in hemotological parameters between groups In the next section, examining biochemical parameters (Fig 4):...
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