I sympathize, I think I barely understand it myself and that's only because I spent a lot of time learning the terminology of regression analyses....
Okay yes, two-stage least squares (2SLS) regression does work by estimating the causal effect as a ratio between the effect of the allele on the...
@dundrum Did I read the neuroscience? Yes. I've been reading it for years. Does it prove that fear, stress, or expectation are driving the...
They are based on evidence that in some specific circumstances, fear stress and expectation may upregulate pain, and then present their treatments...
again, we’re not doubting that this might be true for some group of people of unknown size. We’re arguing against the idea that this can be...
Also, if the same group keeps putting out paper after paper with the same methodological issues, I don't think it is the responsibility of folks...
Just to clarify, the “repurposing” I mention is specifically to explain why the aberrant pain perception arises in the first place. Iirc it was...
And to this point, many such as yourself might point to some patient testimonies, or some small gains in clinical trials, to show that their...
@Friendswithme I did actually get a free copy of Lekander's book and spend some time reading the first few chapters. You were right that he is a...
I think there is something to your point here, because the studies I have read wrt phantom limb pain specifically show a “repurposing” of neurons...
Thanks! If you do try it out again I’d be interested to know. I’d expect the sumac and L-glutamine to have different effects and only the sumac...
I believe that process is what “two-stage least squares regression” refers to in their methods, though I may be wrong about that. If they didn’t...
That would be part of the screening for allelic traits to include/exclude from the polygenic risk score. Alleles would be included if they were...
Yes, sorry, I was exaggerating for the purposes of brief explanation. Individually an allele is not likely to be a perfect predictor for anything...
Completely understandable! Definitely don’t want anyone pushing themselves into PEM to test the hypothesis, just wanted to see if anyone had...
Thanks for sharing your experience!
From my understanding (remembering one lecture several months ago), the idea of MR is to find alleles that are so strongly correlated to your...
I appreciate the warning, thank you for watching out for me. At this point I’ve been on stimulants for about 5 years and have stayed on the same...
I think that is part of it, and also the stimulants increase the threshold of how much I can do total. So maybe with both of those things together...
Interesting! Yeah no sore throat, the only flu-like symptoms I’ve ever gotten are muscle pain and stiffness, feverishness, and then that general...
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